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All Journal Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Nohan Noer Adnan
Universitas Tanjungpura
Health Professions Nursing Public Health

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Efektivitas Senyawa Sulforaphane dari Microgreen Brokoli (Brassica Oleracea) sebagai Immunomodulator (Anti-Pyroptosis Macrophage) dan Antifibrosis Paru untuk Pengobatan Penyakit Tuberkulosis Paru Nohan Noer Adnan; Naufal Issan Beryldivito Iskandar; Ganesha Galang Yudistira
Jurnal Ventilator Vol. 4 No. 2 (2026): Juni : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v4i2.2491

Abstract

Pulmonary tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis and remains one of the leading causes of death worldwide, including in Indonesia. Long-term tuberculosis treatment often results in various problems, such as drug resistance, poor patient adherence, lung tissue damage, and post-infection pulmonary fibrosis. Therefore, innovative natural-based therapeutic approaches are needed to improve treatment effectiveness while minimizing complications. This study aims to examine the potential of sulforaphane (SFN), a phytochemical compound derived from broccoli microgreens (Brassica oleracea), as an immunomodulatory and anti-pulmonary fibrosis agent through nanoencapsulation technology. This study employed a narrative literature review method using scientific databases, including PubMed, Scopus, ScienceDirect, and Google Scholar, covering publications from 2018–2024. Data were analyzed using critical appraisal techniques to systematically evaluate and synthesize previous findings. The review demonstrated that SFN exhibits antioxidant activity by activating the NRF2 signaling pathway, thereby reducing reactive oxygen species (ROS) production, inhibiting NLRP3 inflammasome activation, and preventing macrophage pyroptosis induced by M. 
MICROMETRICS: Teknik Diagnosis Portable Kanker Kolorektal Menggunakan Biomarker MiR-21 Berbasis Point-of-Care Testing (POCT) dengan Metode Colorimetry melalui Nanoparticle-Based Assay Naufal Issan Beryldivito Iskandar; Nohan Noer Adnan; Ganesha Galang Yudistira
Jurnal Ventilator Vol. 4 No. 2 (2026): Juni : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v4i2.2492

Abstract

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and remains the second leading cause of cancer-related mortality. Delayed screening significantly contributes to the high mortality rate of CRC. Current screening methods, such as colonoscopy and Fecal Immunochemical Testing (FIT), are considered gold standards; however, these approaches are invasive, costly, and may cause discomfort or intestinal injury. Therefore, the development of a minimally invasive, affordable, and portable diagnostic method is urgently needed. This study proposes MICROMETRICS, a smartphone-based Point-of-Care Testing (POCT) innovation designed to detect miR-21, a promising biomarker for colorectal cancer, using a colorimetric nanoparticle-based assay. The study employed a literature review method using scientific databases, including PubMed, Google Scholar, ResearchGate, and ScienceDirect. Data were analyzed through descriptive and critical appraisal approaches to design a low-fidelity prototype and evaluate its feasibility using SWOT analysis. The MICROMETRICS system integrates a mini-laboratory hardware setup with smartphone software capable of analyzing color changes generated by interactions between miR-21 and metallic nanoparticles. The captured images are processed through RGB-to-CIELAB color conversion and mathematical algorithms to determine miR-21 concentration quantitatively. The results are then displayed graphically in real time through the application interface. Elevated miR-21 concentrations indicate a positive CRC screening result. Overall, MICROMETRICS demonstrates strong potential as a flexible, cost-effective, rapid, and minimally invasive diagnostic platform for colorectal cancer screening and early detection, particularly in resource-limited healthcare settings.
Co-Authors Ganesha Galang Yudistira Naufal Issan Beryldivito Iskandar