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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Anak Agung Wiradewi Lestari
Departement of Clinical Pathology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah, Bali
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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ACCELERATED-PHASE OF CHRONIC MYELOID LEUKEMIA IN A THIRTEEN-YEAR-OLD BOY: A CASE REPORT I Dewa Agung Gede Agastya Janardhana; Sianny Herawati; Ni Kadek Mulyantari; Anak Agung Wiradewi Lestari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 2 (2026)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i2.2408

Abstract

A myeloproliferative disease known as Chronic Myeloid Leukemia (CML) affects one to 1.5 persons per 100,000 people worldwide. The first cancer that is reliably linked to a particular chromosomal anomaly called the Philadelphia chromosome is chronic myeloid leukemia (CML). A 13-year-old kid was diagnosed with chronic myeloid leukemia seven months ago, which is marked by paleness and lethargy. The test results indicated hyperleukocytosis, anemia, and mild thrombocytopenia. Bone marrow aspiration indicated an accelerated phase CML, with 14.5% of blasts found. The cytogenetic test revealed the existence of the Philadelphia chromosome and a complicated karyotype. The patient has a 10-day therapy and gradually improves their general condition until cleared for discharge. The diagnosis of CML has three distinct phases: chronic, accelerated, and blastic crisis. Blood smears and bone marrow exams show blast numbers of 10% to 19% in the accelerated phase of CML. Cytogenetic tests show Philadelphia chromosomes. The detection of a Philadelphia chromosome on cytogenetic analysis, as well as all forms of myeloid stage with 14.5% myeloblasts, confirms the patient's accelerated-phase CML diagnosis. A thirteen-year old boy with accelerated-phase of CML with positive Philadelphia that showed improvement after hospital treatment and was allowed to go home.
Co-Authors I Dewa Agung Gede Agastya Janardhana Ni Kadek Mulyantari Sianny Herawati