Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Indonesian Journal of Global Health Research
Yuriz Bakhtiar
Universitas Diponegoro & Dr. Kariadi General Hospital

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Herbal Medicine as an Adjuvant Therapy in Experimental Traumatic Brain Injury: A Scoping Review of Types, Dosages, and Treatment Duration in Rat Models Bagaskara Yogatama; Yuriz Bakhtiar; Saekhol Bakri; Muhammad Thohar Arifin
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2400

Abstract

Traumatic brain injury (TBI) is associated with substantial neurological morbidity and mortality, and current therapeutic approaches remain limited in targeting secondary injury mechanisms. This scoping review aimed to summarize the types, dosages, treatment durations, and therapeutic effects of herbal medicine as an adjuvant therapy in experimental TBI models. A literature search was conducted in PubMed, ScienceDirect, Scopus, Springer Link, and additional sources using predefined eligibility criteria focused on rodent TBI models and herbal interventions. Thirteen studies published between 2016 and 2025 were included. Most studies were preclinical experiments using male rats or mice, while two clinical randomized controlled trials involving TBI patients were also identified. The reviewed interventions included Centella asiatica, luteolin, Pycnogenol, rhubarb, rhein, cinnamon extract, Yunnan Baiyao, TH-CD, Xuefu Zhuyu Decoction, and herbal combinations. Treatment duration typically ranged from 3 to 14 days. Overall, herbal interventions demonstrated potential neuroprotective effects by reducing neuroinflammation, oxidative stress, neuronal apoptosis, edema, and disruption of the blood–brain barrier, leading to improvements in neurological, histopathological, and selected clinical outcomes.
Co-Authors Bagaskara Yogatama Muhammad Thohar Arifin Saekhol Bakri