Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kefarmasian Indonesia
Riski Oktaviana Saputri
Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. K.H. Ahmad Dahlan 53142, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Optimization  cocrystal formation of furosemide with malic acid coformer using neat grinding method to improve solubility and dissolution Agus Siswanto; Riski Oktaviana Saputri; Uqie Shabrina Hasyyati
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 2 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i2.2140

Abstract

Furosemide is a Biopharmaceutical Classification System (BCS) Class IV diuretic whose bioavailability is strictly limited by its poor solubility and low permeability. This study aimed to optimize the cocrystallization of furosemide with malic acid as a coformer using the neat grinding method to enhance its solubility and dissolution rate. Optimization was performed using a Simplex Lattice Design (SLD) in Design-Expert 13.0 software. Furosemide (A) and malic acid (B) served as variables ranging from 1 to 2 molar ratios across eight experimental trials. Numerical analysis of saturation solubility and percentage of drug dissolved at 60 minutes (Q60) was conducted to identify the optimal ratio. Cocrystal formation by neat grinding significantly improved both the solubility and dissolution rate of furosemide. The optimal molar ratio of furosemide to malic acid was determined to be 1.339:1.661, achieving a desirability value of 0.965. The resulting optimized capsule formulation fully complied with standard physical properties and dissolution release parameters. In conclusion, neat grinding cocrystallization with malic acid at the optimized ratio effectively enhances the solubility and dissolution profile of furosemide, offering a novel approach for improved drug delivery.
Co-Authors Agus Siswanto Uqie Shabrina Hasyyati