<![CDATA[Background: Eugenia uniflora L. (pitanga) is traditionally used in South America for gastrointestinal disorders. Although in vitro studies have highlighted its antioxidant and α-glucosidase inhibitory properties, quantitative synthesis evaluating its potency and relative predominance remains limited. Objective: To systematically review and synthesize the evidence on the in vitro antioxidant and α-glucosidase inhibitory effects of E. uniflora extracts, with a focus on digestive enzyme inhibition and implications for intestinal health. Methods: Studies published between 2015 and 2025 that evaluated the antioxidant activity of E. uniflora using DPPH, FRAP, and ABTS assays and its α-glucosidase inhibitory activity were analyzed. Data from secondary sources were evaluated using source triangulation to compare plant parts, extraction methods, phytochemical characteristics, and biological activities. Results: E. uniflora consistently exhibited potent α-glucosidase inhibitory activity across extraction methods, particularly in leaf extracts, making enzyme inhibition its most reproducible biological activity. In contrast, antioxidant activity showed greater variability depending on the assay used (DPPH, ABTS, or FRAP), plant organ, and solvent. Conclusion: E. uniflora demonstrates strong potential as a natural α-glucosidase inhibitor. This mechanism may delay carbohydrate digestion, improve postprandial glycemic regulation, and reduce intestinal oxidative stress and osmotic load. Although its antioxidant effects may provide complementary protection, these effects are more variable. Standardized phytochemical characterization, in vivo studies, and clinical trials are needed to confirm its therapeutic efficacy.]]>
