<![CDATA[Background: The success of antiretroviral therapy (ART) in PLHIV is assessed by the achievement of viral load (VL) suppression. SIHA data for June 2025 in Blitar Regency show that the incidence of VL non-suppression reached 17.45%, up from the previous year's 10.70%. The presence of VL non-suppression cases confirms that therapy success problems persist and require further attention. Purpose: This study aims to analyze the determinants of VL non-suppression in PLHIV undergoing ART in Blitar Regency in 2025. Methods: An analytical observational study with a cross-sectional design was conducted in January-February 2026 at four community health centers in Blitar Regency. The study population consisted of 90 PLHIV from four community health centers, and 54 respondents were selected using consecutive sampling. Data on VL examination results, respondent characteristics, employment status, duration of therapy, and opportunistic infections were obtained from the HIV/AIDS Information System (SIHA). Meanwhile, data on medication adherence were collected using the Morisky Medication Adherence Scale (MMAS-8) questionnaire. Data were analyzed using the chi-square test and binary logistic regression. Results: Binary logistic regression analysis showed that medication adherence was the most influential variable for VL non-suppression (aOR=21.32; 95% CI: 3.42–132.96; p=0.00). Respondents who were not adherent to ARTs had a 21.320 times greater risk of experiencing VL non-suppression than adherent respondents. Conclusion: Age ≥50 years and medication adherence were significantly associated with viral load (VL) non-suppression among PLHIV in Blitar Regency. Therefore, medication adherence should be improved, particularly among PLHIV aged ≥50 years.]]>
