<![CDATA[Background: Exogenous steroid administration through hormonal contraceptives is widely utilized globally, yet localized epidemiological evidence regarding its impact on breast tumor incidence remains limited within Indonesian municipal referral centers. Objective: This study evaluated the relationship between hormonal contraceptive use and the incidence of breast tumors among female patients treated at Tangerang City Regional General Hospital (RSUD) from 2020 to 2024. Methods: A retrospective hospital-based case-control study was conducted with 113 age-matched female respondents (<50 years: 90.3%). The cohort comprised 54 histopathologically confirmed breast tumor cases (32 benign, 22 malignant) and 59 non-tumor controls. Data extracted from medical records were analyzed using Chi-Square tests and Odds Ratios (OR) with 95% Confidence Intervals (CI). Findings: Overall contraceptive users demonstrated significantly higher odds of developing breast tumors compared to non-users ("OR"=2.370, p=0.025). Specifically, hormonal contraceptive users faced an 8.31-fold increased risk compared to non-hormonal users ("OR"=8.313, p<0.001), whereas non-hormonal methods showed no significant association ("OR"=0.749, p=0.573). Contraceptive modality did not significantly alter tumor histopathology (benign vs. malignant, p=0.709). Significance: These empirical findings provide valuable institutional data to bridge local research gaps, underscoring the necessity of integrating routine clinical breast examinations into family planning services and guiding high-risk patients toward non-hormonal contraceptive options.]]>
