<![CDATA[Background: Cervical cancer remains a significant women's health issue globally and in Indonesia. The study uses Instagram and Powerpoint, where these media are considered very effective for conveying health education materials to students. Objectives: This study aimed to evaluate the effectiveness of Instagram video media in enhancing knowledge and attitudes among junior high school students in Surakarta, Indonesia. Methods: The research was quasi-experimental study. Cluster random sampling was employed to select participants from two intervention schools, namely The intervention group was conducted at two private junior high schools in Surakarta City. The control group was conducted at one public and one private junior high school in Surakarta City. The intervention group received education through videos shared on Instagram, while the control group used PowerPoint presentations. Data analysis was conducted using SPSS with Wilcoxon and Mann Whitney tests. Results: Based on the Wilcoxon signed-rank test, there was a difference in the mean knowledge scores before and after the use of Instagram and PowerPoint media in both groups, with a p-value of 0.001. Meanwhile, the Mann–Whitney test results showed a significant difference between the use of Instagram media and PowerPoint media in knowledge scores in both groups (p-value < 0.001). However, there was no significant difference between the use of Instagram media and PowerPoint media in attitude scores in both groups (p-value = 0.148). Conclusion: The intervention using Instagram videos significantly improve junior high school students knowledge scores compared to PowerPoint education. Instagram can be a strategic tool for health agencies to raise awareness, prevent, and detect cervical cancer early. However, this must be balanced with valid, consistent content and collaboration with trusted medical professionals to prevent misinformation. Keywords: cervical cancer; instagram; powerpoint; education of cervical cancer; student]]>
