<![CDATA[Background: Hypertension remains a major cardiovascular disorder and continues to contribute substantially to morbidity and mortality. Garlic, or Allium sativum, has been widely studied as a natural agent with potential antihypertensive effects due to its bioactive sulfur compounds and vascular protective properties. Purpose: This study aimed to determine the antihypertensive effect of Allium sativum extract in epinephrine-induced hypertensive Wistar rats and to compare its effect at different dose levels. Methods: This study employed a true experimental pretest-posttest control group design. A total of 20 male Wistar rats were divided into five groups: three treatment groups receiving Allium sativum extract at doses of 50 mg, 100 mg, and 200 mg; one negative control group; and one positive control group receiving amlodipine. Blood pressure was measured before induction, after epinephrine induction, and after treatment. Data were analyzed using a paired-samples t-test and one-way ANOVA. Results: Epinephrine significantly increased systolic and diastolic blood pressure in all groups. After treatment, blood pressure decreased in the extract-treated groups. The 200 mg group showed the greatest mean systolic reduction of 60.50 mmHg (approximately a 33.9% decrease from post-induction values) and a mean diastolic reduction of 39.00 mmHg (approximately a 31.8% decrease). One-way ANOVA showed no significant differences between groups at pretest (p=0.523 systolic; p=0.085 diastolic), while significant differences were found at posttest (p=0.000 for both). Post hoc analysis confirmed that the 200 mg group produced the strongest antihypertensive effect among all tested groups. Conclusion: Allium sativum extract demonstrated significant antihypertensive activity in an epinephrine-induced hypertension model. The 200 mg dose produced the most pronounced reduction in blood pressure (systolic: ~33.9%; diastolic: ~31.8%), establishing a clear dose-response relationship.]]>
