The development of Artificial Intelligence (AI) is increasingly mediating how humans acquire knowledge, make decisions, and perform cognitive activities. In higher education, the delegation of cognitive activities to algorithmic systems has the potential to shift human judgment and responsibility. This study aims to examine Qur’anic anthropology as a foundation for reframing human agency under increasingly AI-mediated conditions. This study employs a qualitative approach using a literature-based design and conceptual analysis. A semantic-contextual analysis is conducted on the Qur’anic terms al-insān, al-bashar, al-nās, Banī Ādam, al-ins, al-mar’, as well as the concepts of ‘abd and khalīfah. The findings are then synthesized with theories of human agency, moral responsibility, and AI ethics. The findings reveal that Qur’anic anthropology represents human beings as multidimensional entities possessing cognitive, relational, moral, spiritual, and teleological capacities. These dimensions are reconstructed into eight capacities of Qur’anic human agency: epistemic, moral, relational, spiritual, and teleological agency. The findings demonstrate that human agency from a Qur’anic perspective is not synonymous with absolute autonomy, but rather constitutes the capacity to understand, evaluate, choose, and act consciously within an orientation of values and responsibility. In the context of AI, Qur’anic Ethical Intelligence (QEI) is conceptualized as an ethical capacity to direct and evaluate the use of AI without surrendering human judgment and responsibility to algorithmic systems. As a conceptual study, this research does not empirically test the application of QEI among university students. Further research is therefore needed to validate and develop measurement instruments. This study connects Qur’anic anthropology with human agency under algorithmic conditions and proposes QEI as a framework for strengthening human agency resilience in the age of AI.