<![CDATA[ Nurses working in multidisciplinary units providing neurological, surgical, and cardiac care experience complex demands related to diverse patient characteristics, nursing needs, and care coordination, which may contribute to fatigue. This study aimed to describe nurses’ experiences of fatigue while providing medical-surgical nursing care in a multidisciplinary service unit. A descriptive qualitative design was conducted through in-depth interviews with 10 nurses selected using purposive sampling in the Rambutan Ward of Sultan Suriansyah Regional Hospital, Banjarmasin, in May 2026. Data were also collected through non-participant observations and document reviews from May to June 2026. Analysis used the Miles and Huberman interactive model, including data reduction, data display, and conclusion verification. Trustworthiness was maintained through triangulation, member checking, peer debriefing, and audit trails. Five themes were identified: complexity of multidisciplinary patient management, factors influencing fatigue, fatigue experiences, impacts of fatigue, and strategies with future expectations. Nurses reported physical, cognitive, emotional, psychological, and overwhelmed fatigue, along with empathic experiences resembling compassion fatigue. Fatigue was associated with organizational factors, patient characteristics, personal factors, and work-environment conditions. Organizational support, effective work-system management, adequate resources, and adaptive strategies are essential to support nurses in managing multidisciplinary care demands.]]>
