<![CDATA[Introduction: Adherence to antihypertensive therapy (AHT) plays a crucial role in achieving optimal blood pressure control and preventing long-term complications, including impaired renal function. This study aimed to analyze the association between medication adherence and blood pressure control and to evaluate renal function in hypertensive patients. Methods: This observational analytic study used a retrospective cohort design. This study was conducted at the Pakem Community Health Center using medical records of hypertensive patients participating in the Chronic Disease Management Program (Program Pengelolaan Penyakit Kronis [PROLANIS]). Blood pressure control was determined based on the average blood pressure measurements over six months. Medication adherence was assessed using the medication possession ratio (MPR) from January to June 2025, while renal function was assessed based on changes in the estimated glomerular filtration rate in January and July 2025. Statistical analyses were performed using IBM SPSS Statistics version 26. Statistical significance was defined as p < 0.05. Results: A total of 101 patients met the inclusion criteria. Most patients had high adherence (78.2%) and controlled blood pressure (72.3%). The proportion of blood pressure control was higher in the high-adherence group than in the low-adherence group (81.0% vs. 40.9%; p < 0.001), patients with high adherence had 6.16 times higher odds of achieving blood pressure control (OR 6.16; 95% CI 2.22–17.08). No significant difference in the estimated glomerular filtration rate was observed between patients with controlled and uncontrolled blood pressure (3.25 ± 7.66 vs. 3.93 ± 10.19 mL/min/1.73 m²; p = 0.970). Conclusion: Medication adherence was significantly associated with blood pressure control, whereas changes in renal function did not differ significantly between patients with controlled and uncontrolled blood pressure.]]>
