Clinton Antony
Sekolah Tinggi Ilmu Kesehatan Mitra Husada Medan, Sumatera Utara, Indonesia

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Risk of Low Birth Weight Among Neonates Born to Mothers With Preeclampsia : A Systematic Review muji rahayu; Rosmani Sinaga; Enda Angina Br Karo; Clinton Antony; Dui Ronala Sihotang
Jurnal Kebidanan Midwiferia Vol. 12 No. 2 (2026): October
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/midwiferia.v12i2.1888

Abstract

Introduction Preeclampsia is a hypertensive disorder during pregnancy that can be associated with placental dysfunction, fetal growth restriction (FGR), preterm birth, and low birth weight (LBW). This systematic review aims to analyze the latest evidence regarding the risk of LBW in neonates born to mothers with preeclampsia and to identify factors that may influence it. Methods The literature search was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 through PubMed, Scopus, ScienceDirect, and Web of Science for primary English-language articles published between January 2022 and December 2025. Studies that met the criteria involved mothers with preeclampsia or hypertensive disorders in pregnancy and reported LBW or birth weight. Five primary studies met the criteria and were included in the qualitative synthesis. The synthesis was carried out narratively because there was heterogeneity in study design, population, exposure definitions, and outcomes. Results The results indicate that preeclampsia is associated with an increased risk of low birth weight (LBW), especially in early onset or severe cases, through placental perfusion disturbances, angiogenesis imbalance, fetal growth restriction, and medically indicated preterm delivery. Neonatal risk is also influenced by maternal comorbidities, gestational age at delivery, antenatal monitoring, and timing of delivery. Discussion and Conclusion Early risk detection, fetal growth monitoring, proper maternal management, and coordination of obstetric and neonatal services are necessary to support the prevention of LBW-related morbidity