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EFEKTIFITAS ANTIKANKER FRAKSI (Curcuma zedoaria) DAN PENGARUHNYA TERHADAP EKSPRESI GEN CASPASE 3 PADA SEL HELA SECARA IN VITRO Sumantri, Apria Wilinda
Jurnal Kesehatan Saelmakers PERDANA (JKSP) Vol 1 No 2 (2018): Jurnal Kesehatan saelmakers perdana
Publisher : Fakultas Ilmu Kesehatan Universitas Katolik Musi Charitas

Aim : The purpose of this research was the evaluate the efficacy of anti-cancer of active fraction of temu putih (Curcuma zedoaria) and their effects on expressetion caspase 3 in Hela cells in vitro Method: Do experimental study in Vitro the research population was whie the Hell cell meanwhile the research sample was HeLa cell that grow normally in cell number of 1 x 104 cell/well. The treatment group was ethanolextract, n-hexane fraction, ethyl acetatefraction and ethanol-water fraction of temu putih (Curcuma zedoaria ) were divided into 6 concentrations, that is 1000, 500, 250, 125, 62,5 dan 31,25 ug/ml; I negative control group ; and the positive control group of cispilatin with a concentration of 200, 100, 50, 25, 12,5 dan 6,25 ug/ml. the data were analyze SPSS Version 20. Result: The research findings showed that the n-hexane fraction of temu putih (Curcuma zedoaria) with the concentration of 154,261 ug/ml has the ability to induce apoptosis of 42.34% and increased the expression of caspase 3of 29,44% in Hell cells. Where as the IC50  Valuve of 20,823 ug/ml. Conclusion :       I can be said that the n-hexane fraction has the equivalent ability tp cisplatin 200 mg/ml in inhibiting growth and its effect on the expression of caspase 3 in HeLa cells In Vitro Keywords : N-hexane fraction, Temu putih (Curcuma zedoaria), anti-cancer, HeLa cells, Caspase 3

HUBUNGAN KENAIKAN BERAT BADAN DENGAN LAMA PEMAKAIAN KONTRASEPSI SUNTIK 3 BULAN Sumantri, Apria Wilinda
Jurnal Kesehatan Saelmakers PERDANA (JKSP) Vol 2 No 2 (2019): Jurnal Kesehatan Saelmakers PERDANA
Publisher : Fakultas Ilmu Kesehatan Universitas Katolik Musi Charitas

Family planning is the most basic and primary preventive health care effort, as well as the prevention of death. Family planning services can be done with the use of contraceptives. Contraceptive 3-month injection is a type of fluid injected into the female body intramuscularly (3 months) . To know weigh relationhip increasemen wingh the use of 3 month injectable village laya working area UPTD community health center tanjung agung baturaja barat 2018 year. of Analytic survey research with cross sectional approach. sample research taken by accidental sampling with a large sampe of 30 respondents Data can be by using the observation instrument, after all data collected then performed data processing using SPSS program version 22, .. Univariate analysis result, from 80 respondents found 57 (71,2%) using injectable contraception, 43 (75,4%) who gained weight, 14 (24,6%) who did not gain weight. From result of statistic analysis obtained pvalue: 0,02. The existence of 3 Months KB Injections Connection with Weight Gain Increase in Laya Work area UPTD Puskesmas Tanjung Agung Year 2018. Relationship increasment wing the use of 3 month injectable. Increasement weingh, cross sectional, statistical test Chi-Squeare.

HUBUNGAN KEPATUHAN MENGKONSUMSI TABLET FE TERHADAP KEJADIAN ANEMIA DIWILAYAH KERJA UPTD PUSKESMAS KEMALARAJA KABUPATEN OKU TAHUN 2015 Sumantri, Apria Wilinda
Masker Medika Vol 5 No 1 (2017): Masker Medika
Publisher : IKesT Muhammadiyah Palembang

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Anemia adalah suatu keadaan adanya penurunan kadar hemoglobin, hematokrit, dan atau jumlah eritrosit diabawah nilai normal. Tindakan yang dilakukan untuk mengtatasi masalah tersebut selama ini adalah pendistribusian tablet Fe. Faktor utama yang menyebabkan sulitnya prevalensi anemia ini antara lain karena rendahnya cakupan distribusi dan kepatuhan ibu mengkonsumsi tablet besi. Tujuan : untuk mengatahui hubungan kepatuhan mengkonsumsi tablet Fe terhadap kejadian anemia di wilayah kerja UPTD Puskesmas Kemalaraja kabupaten OKU tahun 2015. Metode : penelitian ini menggunakan metode analitik dengan pendekatan cross sectional. Populasi penelitian ini adalah ibu hamil bulan januari â€“ maret tahun 2015 di wilayah kerja UPTD Puskesmas Kemalaraja kecamatan Baturaja Timur Kabupaten OKU dengan sampel sebanyak 75 orang. Analisi data menggunakan analisis univariat dan analisis bivariat dengan menggunakan tabel distribusi dan uji statistik chi-square, dengan derajat kepercayaan 95 %. Hasil : pada anisis univariat, dari 75 responden didapatkan 32% ibu hamil yang mengalami anemia, dan 68% ibu hamil yang tidak anemia. Ibu hamil yang mengkonsumsi tablet Fe 61,3%, dan ibu hamil yang tidak patuh mengkonsumsi tablet Fe 38,7%. Analisis bivarian didapatkan hasil ada hubungan kepatuhan mengkonsumsi tablet Fe terhadap kejadian anemia (p value 0,000). Simpulan : ada hubungan kepatuhan mengkonsumsi tablet Fe terhadap kejadian anemia

UJI AKTIVITAS SITOTOKSIK DARI TUMBUHAN TEMU PUTIH (Curcuma zedoaria) ASAL KABUPATEN OGAN KOMERING ULU Sumantri, Apria Wilinda
Masker Medika Vol 7 No 2 (2019): Masker Medika
Publisher : IKesT Muhammadiyah Palembang

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Latar belakang: Kanker adalah suatu penyakit yang disebabkan oleh pertumbuhan sel-sel jaringan tubuh yang tidak normal. Pengobatan kanker selain menggunakan obat kimia, juga dapat menggunakan agen phytotherapeutic, yaitu obat herbal standar yang terdiri dari bahan aktif yang berasal dari bagian tanaman. Beberapa penelitian mengatakan bahwa temu putih (Curcuma zedoaria) merupakan salah satu tumbuhan berkhasiat yang dapat diolah menjadi obat herbal. Kandungan senyawa kimia pada kunyit putih mengandung banyak manfaat seperti antikanker, antifungal, antiamebic, larvasida, antimikroba, antioksidan, antiplasmodial, antialergi, dan analgetik. Hasil: Hasil skrining fitokimia terhadap serbuk simplisia dan ekstrak etanol tumbuhan temu putih (Curcuma zedoaria) asal Kabupaten OKU mengandung senyawa aktif golongan flavonoid, tanin dan saponin. Tumbuhan sarang semut ini memiliki potensi aktivitas sitotoksik yang tinggi dengan nilai LC50 < 1000 ppm, yaitu dengan nilai LC50 sebesar 22,86 ppm terhadap ekstrak etanol temu putih (Curcuma zedoaria). Kesimpulan: temu putih mengandung senyawa kimia kurkuminoid, RIP (Ribosome Inacting Protein), isocurcumenol, demothxycurcumin, bisdemothxycurcumin, epicurzerenone, curdione, dan ethyl p- methoxycinnamate yang berfungsi menonaktifkan perkembangan sel kanker dan menghambat pertumbuhan sel kanker. Selain itu, kunyit putih juga mengandung senyawa kimia seperti curzerenone, zedoaron, minyak atsiri, diferuloylmethan, flavonoid, kurkumin, trimethoxyflavone, tetramethoxyflavone, tetrahydrodemethoxycurcumin, dihydrocurcumin, dan polifenol yang bermanfaat secara farmakologis. Bagkground: Cancer is a disease caused by the growth of body tissue cells that are not normal. Treatment of cancer other than using chemical drugs, also can use phytotherapeutic agent, that is a standard herbal consist of active subtances derived from plant parts. Some studies suggest that white turmeric (Curcuma zedoaria) is one of the herbs that can be processed into herbal medicine. Result: The results of phytochemical screening for simplicia powder and ethanol extract of Curcuma zedoaria from OKU Regency contain active compounds of flavonoids, tannins and saponins. This ant nest plant has a high potential for cytotoxic activity with an LC50 value <1000 ppm, ie with an LC50 value of 22.86 ppm for ethanol extract of Curcuma zedoaria. The chemical subtances on white turmeric contains a lot of benefits such as anticancer, antifungal, antiamebic, larvicides, antimicrobial, antioxidant, antiplasmodial, hypoallergenic, and analgesics. Conclution: that white turmeric contains chemical subtances like curcuminoid, RIP (Ribosome Inacting Protein), isocurcumenol, demothxycurcumin, bisdemothxycurcumin, epicurzerenone, curdione, and ethyl p-methoxycinnamate which serves to disable the development of cancer cells and inhibits the growth of cancer cells. In addition, white turmeric also contains chemical subtances such as curzerenone, zedoaron, essential oils, diferuloylmethan, flavonoids, curcumin, trimethoxyflavone, tetramethoxyflavone, tetrahydrodemethoxycurcumin, dihydrocurcumin, and polyphenols as pharmacological benefits.

Hubungan Konsumsi Mengandung Tinggi Purin Dengan Penyakit Asam Urat Di Desa Air Paoh Kabupaten OKU Tahun 2024 Sumantri, Apria Wilinda
Jurnal Kesehatan Abdurrahman Vol 13 No 2 (2024): Jurnal Kesehatan Abdurahman
Publisher : STIKES Abdurahman. Pusat Informasi dan Manajemen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55045/jkab.v13i2.207

Asam urat adalah penyakit yang ditandai dengan serangan tiba-tiba dan berulang yang disertai radang sendi. Artritis sangat menyakitkan karena konsentrasi asam urat yang tinggi dalam darah (hiperurisemia) menyebabkan kristal monosodium urat terbentuk dan menumpuk di persendian. Secara umum tujuan penelitian adalah untuk mengetahui hubungan konsumsi tinggi purin dengan penyakit asam urat di Desa Air Paoh Kabupaten OKU pada tahun 2024. Penelitian ini merupakan penelitian dengan menggunakan pendekatan cross-sectional dan metode korelasional kuantitatif dengan jumlah sampel sebanyak 50 orang. Variabel-variabel yang diteliti disajikan dalam bentuk tabel frekuensi dan dianalisis terhadap 50 responden dengan menggunakan kuesioner data demografi, kuesioner pengukuran asupan purin tinggi, dan kuesioner pengukuran kadar asam urat analisis univariat dan bivariat. Terdapat 22 responden (64,7%) yang sering memiliki kadar asam urat tinggi dan konsumsi purin tinggi, dan 0 (0,0%) responden yang memiliki kadar asam urat tinggi tetapi hampir tidak ada konsumsi purin. Asupan purin seringkali tinggi, dan 16 (100,0%) responden mengontrol kadar asam uratnya, namun asupan purin jarang yang tinggi. Hasil uji chi-square menunjukkan p-value sebesar 0,000. Artinya ada hubungan antara asupan makanan kaya purin dengan penyakit asam urat di Desa Air Paoh Kabupaten OKU pada tahun 2024. Kesimpulan penelitian terdapat hubungan antara asupan purin tinggi dengan penyakit asam urat di Desa Airpao Kabupaten OKU pada tahun 2024.

Relationship between the Level of Knowledge and Education of Mothers Regarding Fever Management in Children 1-5 Years: A Cross-sectional Study Sumantri, Apria Wilinda
Lentera Perawat Vol. 6 No. 2 (2025): April - June
Publisher : STIKes Al-Ma'arif Baturaja

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52235/lp.v6i2.479

Fever is one of the common health problems in children under five that can cause serious complications if not treated appropriately. Maternal knowledge and education level are important factors in determining the quality of fever management in children. This study aims to analyze the relationship between the level of knowledge and education of mothers with fever management in children aged 1-5 years. This study used a cross-sectional design with a total of 30 maternal respondents who had children aged 1-5 years and visited the Penyandingan Health Center in January 2025. Total sampling technique was used, and data were collected through questionnaires and checklists. Bivariate analysis was performed using the Chi-Square test with a significance value of α = 0.05. The majority of respondents (70%) had good knowledge, and 63.3% of mothers performed fever management correctly. There was a significant relationship between maternal knowledge and fever management (p = 0.004), and between maternal education and fever management (p = 0.002). Maternal knowledge and education were significantly associated with the quality of fever management in children. Continuous educational interventions are needed for mothers of toddlers to improve knowledge and skills in fever management to prevent complications in children.

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