Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro
Prawara, Ananta Siddhi
Unknown Affiliation
Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PENGARUH PEMBERIAN VITAMIN C TERHADAP KADAR GLUTATION (GSH) TIKUS SPRAGUE DAWLEY YANG TERPAPAR HEAT STRESS Prawara, Ananta Siddhi; Johan, Andrew; Jusup, Innawati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 1 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.791 KB) | DOI: 10.14710/dmj.v7i1.19339

Abstract

Latar Belakang: Heat stress adalah suatu keadaan dimana sistem termoregulator tidak dapat mengendalikan keseimbangan temperatur tubuh. Heat stres disebabkan oleh peningkatan suhu lingkungan dan pekerjaan yang berhubungan dengan suhu tinggi. Heat stress memiliki efek yang berbahaya bagi tubuh karena dapat menyebabkan peningkatan kadar dari reactive oxygen species (ROS). Salah satu antioksidan yang bertanggung jawab untuk mereduksi ROS adalah Glutation (GSH). GSH kadarnya akan menurun ketika tubuh terpapar heat stress. Vitamin C digolongkan sebagai antioksidan sistem pertahanan primer berdasarkan kemampuannya mendonorkan elektron untuk mencegah terjadinya oksidasi pada senyawa lain dengan bertindak sebagai agen pereduksi.Tujuan: Menganalisis pengaruh pemberian vitamin C untuk mencegah penurunan kadar GSH pada tikus Sprague Dawley yang terpapar heat stress.Metode: Penelitian ini true experimental randomized post-test only with control group design pada tikus yang dibagi ke dalam tiga kelompok yaitu satu kelompok kontrol negatif (K1) yang tidak diberikan induksi heat stress dan vitamin C, satu kelompok kontrol positif (K2) yang diberikan pemaparan heat stress 43oC selama 70 menit. Kelompok perlakuan (P) yang diberikan vitamin C dengan dosis 0,075 mg/g berat badan melalui sonde lambung 2 jam sebelum pemaparan heat stress 43oC selama 70 menit.Hasil: Kadar GSH kelompok kontrol negatif (K1) lebih tinggi 32,16% dibandingkan kadar GSH kelompok kontrol positif (K2) meskipun secara statistik tidak signifikan dengan p=0,525. Kadar GSH kelompok perlakuan (P) lebih tinggi 144,44% dibandingkan kadar GSH kelompok kontrol positif (K2) meskipun secara statistik tidak signifikan dengan p=0,134.Kesimpulan: Pemberian vitamin C dapat mencegah penurunan kadar GSH tikus Sprague Dawley yang terpapar heat stress.
Case Reports of Left Atrial Myxoma in Elderly and Children Laksono, Sidhi; Surya, Steven Philip; Manuputty, Ferel; Lasanudin, Hengkie Frankie; Prawara, Ananta Siddhi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): June 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.24 KB) | DOI: 10.30659/sainsmed.v12i1.11632

Abstract

Introduction: Cardiac myxoma is a rare heart disease. Cardiac myxoma can manifest in both intracardiac and extracardiac. This report describes the importance of a careful history taking, physical examination, echocardiography, and complete surgical resection for the management of atrial myxoma in two patients.Case Reports: We reported two cases: a 64 years old female and a 16 years old male with neurological deficit as the chief complaint. The two patients underwent brain imaging and echocardiography evaluation. Both were diagnosed with left atrial myxoma and brain infarction. Surgical resection of the left atrial myxoma was successfully done in both patients and afterward, both were being monitored in the outpatient clinic. During follow up, a gradual clinical improvement can be seen in the right extremities. Echocardiography examination was conducted at 1 month, 3 months, and 6 months follow-ups for both patients and no abnormalities were found. Discussion: Atrial myxomas are the most common primary cardiac tumors. Systemic embolization in atrial myxoma is uncommon manifest as neurological deficit with reported incidence around 20-35%. On the other hand, in stroke or transient ischemic attack patients, atrial myxoma were found in 1 out of 250 young adults and 1 out of 750 older patients. Transthoracic echocardiography (TTE) has up to 95% sensitivity on diagnosing atrial myxoma. The long-term prognosis of the patients when diagnosed and managed correctly is very good and surgery is curative with recurrence rate 1-3%. The patients in our case reports showed gradual clinical improvement with no sign of myxoma recurrence during follow up.Conclusion: Stroke is one of the extracardiac manifestations of atrial myxoma. Thus, it is crucial to evaluate the presence of atrial myxoma in stroke patients. The use of TTE is important in diagnosing atrial myxoma. Resection of atrial myxomas is curative with excellent long-term prognosis and low chance of recurrences.
Co-Authors Andrew Johan Innawati Jusup Laksono, Sidhi Lasanudin, Hengkie Frankie Manuputty, Ferel Surya, Steven Philip