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I Made Arya Subadiyasa
Sultan Ageng Tirtayasa University

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Role of C-Reactive Protein as an Inflammation Biomarker in Women of Reproductive-Age : Literature Review Neshya Ruriana Putri; Maulana Hasymi Hutabarat; I Made Arya Subadiyasa
International Journal of Medicine and Public Health Vol 2, No 1 (2025): April
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/inomed.v2i1.33610

Abstract

C-reactive protein (CRP) is a well-known acute phase inflammatory biomarker that can rise dramatically in response to inflammation. In reproductive-age women, several estrogen-related conditions are associated with chronic low-grade inflammation, wherein CRP may serve as a useful marker. This literature review focuses on the role of CRP in conditions influenced by estrogen – notably polycystic ovary syndrome (PCOS) with an emphasis on findings from the last 10 years and data pertinent to Indonesian women. A systematic search of PubMed and Scopus was conducted for 2015–2025 studies on CRP in these conditions. Key findings include evidence of moderately elevated CRP levels in women with PCOS (even after controlling for obesity), Additionally, normal menstrual cycle variations and premenstrual syndromes have been linked to fluctuations in CRP. These findings underscore CRP’s potential as a non-specific marker of inflammation in estrogen-related gynecologic conditions. However, the utility of CRP for diagnosis or prognosis in these conditions is limited by its lack of specificity. Further research, particularly in Indonesian populations, is needed to clarify CRP’s clinical value in managing estrogen-related disorders.
Co-Authors Maulana Hasymi Hutabarat Neshya Ruriana Putri