Immunization is a deliberate preventive effort that protects infants or toddlers from diseases of infection. Basic immunization provides initial immunization to reach immunity above the threshold of protection. Immunization programs are part of health services conducted by governments to reduce infant pain, disability and death. Part of a parent's participation in a health program is influenced by various factors, including knowledge and attitude in the health program itself. This research is aimed at knowing the mother's knowledge and attitude toward the complete immunization of the region of the shoulder loq of the Kunjang Samarinda river region. The purpose of this study is to know the relation of knowledge and motherhood to the efficacy of basic immunization in infants 0-12 months in the area sub distric Loq Bahu Sungai Kunjang Samarinda. Research methods used are observational analytics using a sectional study design. Research indicates there isa correlation between the knowledge of basic immunization in infants 0-12 months in the area sub distric Loq Bahu Sungai Kunjang Samarinda with p value (0.004) < α (0.05),There is a connection between the mother's attitude toward complete base immunization in baby 0-12 months with p value (0.020) < α (0.05),There is no correlation between the maternal age factor in providing basic immunization of infants at 0-12 months with p value (0.493) > α(0.05),The level of education is no relation between the mother's education to the efficacy of basic immunization in infants 0-12 months with p value (1,000) > α (0.05).There is no link between mother's work and the allowance of basic immunization of 0-12 months at baby with p value (0.570) > α (0.05).