<![CDATA[Background: Although percutaneous coronary intervention (PCI) improves survival and clinical outcomes in patients with acute coronary syndrome (ACS), many patients continue to experience impaired health-related quality of life (HRQoL). However, the direct determinants and mediating pathways influencing HRQoL among patients with ACS following PCI remain incompletely understood.Purpose: This study aimed to test the relationships among determinants of HRQoL based on the revised Wilson and Cleary’s model in patients with ACS following PCI.Methods: This cross-sectional study involved 240 patients recruited through consecutive sampling. Data were collected using the Cardiac Self-Efficacy Scale, Fatigue Assessment Scale, Seattle Angina Questionnaire-7, Depression Anxiety Stress Scale 21, Social Functioning Questionnaire, and MacNew Quality of Life Questionnaire. Structural equation modeling was performed with SmartPLS version 3.2.7.Results: Self-efficacy, fatigue, anxiety, and social functioning had significant direct effects on HRQoL (β = 0.276, β = -0.151, β = -0.152, and β = 0.307, respectively; p < 0.05). Social functioning had the greatest direct effect (β = 0.307, f2= 0.219), whereas self-efficacy had the greatest total effect on HRQoL (β = 0.789, f2= 0.166).Conclusion: Self-efficacy, fatigue, anxiety, and social functioning were significant determinants of HRQoL in patients with ACS following PCI. These findings may inform comprehensive patient assessment and the development of targeted, patient-centered nursing care strategies to improve HRQoL.]]>
