Abstract Objective: This study aims to identify and synthesize factors influencing employee well-being in the modern work environment, based on prior research. Research Methodology: The study employed the Systematic Literature Review (SLR) method following PRISMA guidelines. Literature was searched via ScienceDirect, Google Scholar, SpringerLink, and ProQuest for the period of 2020–2025. Of the 1,482 identified articles, 14 met the inclusion criteria and were systematically analyzed. Results: The synthesis indicates that employee well-being is associated with organizational, social, and personal resources, as well as digital/job demands. Identified factors include leadership, leader-member exchange, internal corporate social responsibility, digital leadership, organizational and social support, career crafting, growth mindset, resilience, and grit. Meanwhile, technostress and digital job demands can increase work pressure and potentially diminish employee well-being if not balanced by adequate resources. Conclusion: Employee well-being is influenced by the interaction between organizational, social, and personal resources and job demands. Therefore, enhancing employee well-being requires an integrated approach involving effective leadership, organizational and social support, individual capacity building, and the management of digital work demands.. Limitations: The research was limited to English-language articles from the 2020–2025 period across four databases and included only 14 studies that met the inclusion criteria. Contribution: This study provides an integrative synthesis of the determinants of employee well-being in the modern workplace and can serve as a reference for future research and for organizations developing human resource management strategies that support employee well-being.