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Eleventi Oktarina Putri
Universitas Palangka Raya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology

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Perbandingan Nilai Hematokrit Sebelum dan Sesudah Terapi Tirosin Kinase Inhibitor pada Pasien Chronic Myeloid Leukemia Muhammad Ihza Lisan Shidqi; Yanti Sunaidi; Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari : December 2025
Publisher : Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v8i1.382

Abstract

Chronic Myeloid Leukemia (CML) is a hematologic malignancy characterized by the presence of the Philadelphia chromosome and the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have revolutionized CML management, improving patient survival and quality of life. However, evidence regarding the effect of TKI therapy on simple hematologic parameters, particularly hematocrit values, remains limited. This study aimed to analyze the differences in hematocrit levels before and after TKI therapy in patients with CML. A quantitative comparative design was conducted involving 53 CML patients (32 males, 21 females) aged 19–66 years. Hematocrit values were collected from medical records at two points: prior to therapy and after twelve months of TKI treatment. Data distribution was assessed using the Shapiro-Wilk test, and comparisons were performed using a paired sample t-test with a significance level of p < 0.05. The mean hematocrit value before therapy was 29.7%, increasing to 36.7% after therapy, with an average rise of 7.0%. Of the total patients, 42 (79.2%) showed an increase in hematocrit, while 11 (20.8%) demonstrated a decrease. Statistical analysis confirmed a significant difference between pre- and post-therapy values (p < 0.001). TKI therapy significantly improves hematocrit levels in CML patients, reflecting restored hematopoiesis and improved hematologic status. Hematocrit may serve as a practical and cost-effective parameter for monitoring therapy effectiveness, especially in healthcare settings with limited access to molecular testing.
Gambaran Indeks Aterogenik Plasma Pada Penderita Diabetes Melitus Yanti Sunaidi; Sulfiani; Sefhia Purnama Dita; Muhammad Ihza Lisan Shidqi; Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari : December 2025
Publisher : Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by elevated blood glucose levels due to abnormalities in insulin secretion or insulin resistance. This condition increases the risk of cardiovascular disease by triggering dyslipidemia, which is marked by elevated cholesterol, increased levels of low-density lipoprotein (LDL), increased triglycerides, and decreased high-density lipoprotein (HDL) in the blood. Dyslipidemia in diabetic patients is associated with a higher Atherogenic Index of Plasma (AIP), which plays a role in the development of atherosclerosis, a key factor in cardiovascular disease. The logarithmic ratio of triglycerides to HDL can be used to determine the AIP, which serves as a marker for assessing atherogenicity and the risk of cardiovascular disease. This study aimed to predict cardiovascular disease in patients with diabetes mellitus through the evaluation of AIP values. The research was descriptive, involving 32 subjects selected using purposive sampling, and conducted at Dr. Tadjuddin Chalid General Hospital, Makassar, South Sulawesi. Based on the results of 32 subjects: 0 subjects (0%) were categorized as having low cardiovascular risk AIP, with an average value of 0; 1 subject (3%) was in the moderate risk category, with an average AIP of 0.19; 31 subjects (97%) were in the high cardiovascular risk category, with an average AIP of 0.82. These findings indicate that most diabetic patients tend to have a high-risk cardiovascular disease, compared to moderate or low-risk categories.
Co-Authors Antoni Aldo Danendra Sawal Muhammad Ihza Lisan Shidqi Sefhia Purnama Dita Sulfiani Yanti Sunaidi