Abstract: This study examines the effect of personality factors and competence on entrepreneurial career preferences among Generation Z. The research focuses on the dynamics of career choice in entrepreneurship amid employment challenges for university graduates. The novelty of this study lies in its specific focus on Generation Z in Tangerang City, including active students and fresh graduates. This study combines psychological aspects (personality) and skills (competence) to assess the readiness of the younger generation in facing modern business ecosystems in urban areas. This study uses a quantitative approach, with data gathered through questionnaires. Multiple linear regression analysis was used to test the influence of personality and competence variables on business interest, both partially and simultaneously. The results show a positive and significant relationship between personality factors and business career preferences. Similarly, competence has a significant effect in encouraging individuals to choose an entrepreneurial path. Both variables play an important role in shaping Generation Z's confidence and mental readiness, showing that internal drives and technical capabilities are key foundations in career choice. This study is limited to Tangerang City and Generation Z, so the results cannot be generalized to all regions or generations. The implications of this research can serve as a basis for educational institutions in designing integrated entrepreneurship curricula.Keywords: Personality traits, competence, generation z, career preferences, business.