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All Journal Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Cindy Marseli
Sriwijaya University, Palembang, Indonesia
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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PEMBENGKAKAN PERI-ARTICULAR DAN NYERI SENDI AKIBAT AMLODIPINE: SUATU REAKSI OBAT YANG TIDAK DIKEHENDAKI DENGAN ONSET LAMBAT : SEBUAH LAPORAN KASUS Cindy Marseli; Intan Trisakti; Rafifah Azzahra; Falerina Puspita
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.325

Abstract

Amlodipine is a widely prescribed calcium channel blocker that is generally well tolerated, with peripheral edema being its most recognized adverse drug reaction (ADR). Musculoskeletal complaints such as arthralgia and peri-articular swelling have been reported but remain exceedingly rare and poorly characterized. We report a case of recurrent joint pain and peri-articular swelling in a 64-year-old woman receiving long-term amlodipine 10 mg daily. Symptoms appeared several hours after each dose and resolved within 48-72 hours of drug discontinuation. No alternative causes were identified, and clinical evaluation excluded gout and inflammatory arthritis. Cessation of amlodipine resulted in marked symptomatic improvement, and antihypertensive therapy was switched to candesartan. The Naranjo Algorithm yielded a score of 7, indicating a probable ADR. This case highlights a rare musculoskeletal reaction, potentially linked to amlodipine-induced periaortic edema or tissue susceptibility, in older patients with multimorbidity. Early recognition of such atypical ADRs is essential to prevent unnecessary morbidity and to strengthen pharmacovigilance data.
FORMULASI DAN UJI ANTIOKSIDAN GEL MOISTURIZER EKSTRAK BIJI KOPI HIJAU ROBUSTA (Coffea canephora Pierre ex A. Froehner) DENGAN METODE DPPH Tiara Ramadaini; Muhammad Andry; Cindy Marseli; Rafifah Azzahra; Nurfitriyana; Lilik Septiana; Siti Nurhaliza
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.327

Abstract

Robusta green coffee beans (Coffea canephora) are recognized for their abundant chlorogenic acid content, a bioactive compound with significant antioxidant capacity capable of neutralizing free radicals that contribute to dermal damage. The gel dosage form was selected owing to its lightweight consistency, rapid dermal absorption, and combined moisturizing and protective properties. This study aimed to produce a physically and organoleptically stable gel formulation derived from robusta green coffee bean extract, with emphasis on optimizing antioxidant activity as assessed by the DPPH method through IC₅₀ determination. An experimental laboratory approach was employed, utilizing beans obtained from Parapat, Toba region. The study encompassed three sequential stages: plant material extraction, gel preparation, and comprehensive physicochemical stability assessment. Extraction produced an 11.15% yield. Characterization of the crude extract met established quality parameters, with moisture content at 2.5%, water-soluble extract at 13.3%, ethanol-soluble extract at 13.6%, total ash at 3.33%, and acid-insoluble ash at 0.5%. All three gel formulations (F1, F2, F3) exhibited characteristic coffee organoleptic profiles, maintained homogeneity, demonstrated stable pH values ranging from 6.2 to 6.7, displayed satisfactory spreadability, and caused no skin irritation. Moisturization parameters including skin hydration, wrinkle reduction, and pore appearance were improved across all formulations. Formulation F3, containing 9% extract, delivered the highest antioxidant efficacy with an IC₅₀ of 53.157 ppm, placing it in the strong antioxidant category. Robusta green coffee bean extract was successfully incorporated into a stable and safe gel moisturizer with strong antioxidant activity. A direct relationship was observed between extract concentration and both moisturizing performance and free radical scavenging capability.
Co-Authors Falerina Puspita Intan Trisakti Lilik Septiana Muhammad Andry Nurfitriyana Rafifah Azzahra Siti Nurhaliza Tiara Ramadaini