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All Journal Indonesian Journal of Jamu
Mashuri Yusuf
Study Program of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta 11510, DKI Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Indonesian Medicinal Plants Investigated for Cancer-Related Activity: A Review of Ethnobotanical, Phytochemical, and Preclinical Evidence Mashuri Yusuf; Muhaimin Muhaimin; Yoppi Iskandar; Riezki Amalia; Syuhada Syuhada
Jurnal Jamu Indonesia Vol. 11 No. 6 (2026): November–December 2026
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i6.593

Abstract

Medicinal plants are widely used by Indonesian cancer patients, but the evidence behind this use differs in kind and strength. This review classified 24 studies from Google Scholar, ScienceDirect and PubMed, plus ten further primary studies, by evidence level: traditional use, general toxicity, cancer-cell cytotoxicity, measured mechanism, in silico prediction and compound identification. Cancer-cell data existed for 15 of 17 taxa, almost all as crude extracts, and normal-cell controls were rare. The lowest IC50 values were 23.7 µg/mL (Caulerpa racemosa hexane extract, MCF-7) and 54.48 µg/mL (Zanthoxylum acanthopodium fruit ethanol extract, 4T1). The name bajakah covered species of three genera. Mechanisms were measured only for curcumin, Stenochlaena palustris and Ocimum tenuiflorum, and no in vivo efficacy study was found. Botanical authentication, selectivity testing, compound isolation and animal studies should precede therapeutic claims.
Co-Authors Muhaimin Muhaimin Riezki Amalia Syuhada Syuhada Yoppi Iskandar