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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Nur 'Indah Suci Timur
Universitas Setia Budi
Medicine & Pharmacology

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PENGARUH VARIASI PROPILEN GLIKOL DAN ASAM OLEAT SEBAGAI PENETRATION ENHANCER SEDIAAN EMULGEL  BENZOYL PEROXIDE 2,5% DAN NIACINAMIDE 5%TERHADAP BAKTERI Staphylococcus epidermidis Nur 'Indah Suci Timur; Dewi Ekowati; Destik Wulandari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 2 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i2.2643

Abstract

Benzoyl peroxide and niacinamide have a function to cure bacterial infections and acne. The combination of oleic acid with propylene glycol as an enhancer can increase intracellular drug movement and help transfer oleic acid to the site of action. The purpose of this study was to determine the physical quality and stability of emulgel preparations and the effectiveness of emulgel preparations with the addition of penetration enhancers propylene glycol and oleic acid on healing infections in male New Zealand White rabbits that had been injected with S. epidermidis bacterial suspension. This research method is an experimental preventive test with an in vivo test method using male New Zealand White rabbits using 5 rabbits on the back of the skin shaved and the part into 4 parts then given 6 treatments, F1 (propylene glycol 10%), F2 (propylene glycol 5% and oleic acid), F3 (oleic acid 10%), negative control (without the addition of propylene glycol and oleic acid), positive (clindamycin gel 1%), and without treatment. The results of the emulgel formulations showed significant differences before and after the cycle test, both in pH and viscosity. The results showed that the addition of penetration-enhancing ingredients can affect the infection healing process in each formula. Formula 2, with the addition of propylene glycol and oleic acid (5%: 5%), was the best formula for infection healing effectiveness in reducing the erythema diameter score. Formulas 1 and 3 had good physical quality and stability.
Co-Authors Dewi Ekowati Wulandari, Destik