Natural hazards can trigger technological accidents (Natech) at industrial facilities that handle or store hazardous chemicals and hazardous and toxic waste (Bahan Berbahaya dan Beracun, B3), potentially resulting in cascading events, including loss of containment, fires, explosions, atmospheric releases of hazardous substances, soil and water contamination, and operational disruptions. This study aimed to develop an integrated approach to strengthening industrial resilience by incorporating B3 emergency management into Natech risk mitigation strategies. A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Relevant publications from 2016 to 2026 were identified through Scopus, Web of Science, ScienceDirect, and Google Scholar. Of the 537 records identified, 13 articles met the inclusion criteria and were examined using descriptive analysis and thematic synthesis. The findings revealed an increasing emphasis on quantitative risk assessment, dynamic modeling, and spatially explicit predictive approaches to Natech risk management. Critical vulnerabilities included failures of safety barriers, inadequate emergency response capacity, resource constraints, and insufficient institutional coordination. Based on these findings, the study proposed an integrated framework comprising five components: Risk Integration, Safety Barrier Enhancement, Integrated Emergency Preparedness, Recovery and Resilience, and Learning and Adaptation. This framework provided a comprehensive strategy for strengthening integrated Natech–B3 risk management, improving emergency preparedness, and enhancing industrial resilience in Indonesia.