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All Journal Journal of Biomedicine and Translational Research Jurnal Biosains Pascasarjana GENIUS JOURNAL (General Nursing Science Journal)
Jessica Juan Pramudita
Poltekkes Kemenkes Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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CHARGE Syndrome: An Indonesian Case Report Jessica Juan Pramudita; Agustini Utari; Tri Indah Winarni; Sultana MH Faradz
Journal of Biomedicine and Translational Research Vol 3, No 1 (2017): July 2017
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.325 KB) | DOI: 10.14710/jbtr.v3i1.1225

Abstract

Background: CHARGE syndrome is an autosomal dominant congenital and rare genetic disease.The prevalence of CHARGE syndrome approximately 1:12,000 births.In the previous study, the CHD7 gene mutation is responsible in about 2/3 cases of CHARGE syndrome.  The syn­drome associations consist of C-coloboma of the eyes, H-heart disease, A-atresia of the choanae, R-retarded growth and development, G-genital hypoplasia/genitourinary anomalies and E-ear anomalies and/or hearing loss. All defects are not seen in every case and a different spectrum of associations is seen in most of the cases.Method: Case was undergone physical examination by experience pediatricians, pedigree construction, and other diagnostic procedure (X-ray, echo­cardiography, and multi slice computer tomography (MSCT) scan).Results: A boy aged 2 years 9 months with clinical features with match major and minor criterias of CHARGE syndrome.
Design of an Information System for Testing the Blood Characteristics on Increasing the Impact of Vibration using a Prototype “Blood Shaker Machine” Jessica Juan Pramudita; Edy Susanto; Luthfi Rusyadi
Genius Journal Vol. 3 No. 2 (2022): GENIUS JOURNAL
Publisher : Inspirasi Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (899.478 KB) | DOI: 10.56359/gj.v3i2.153

Abstract

Objective: The general purpose of this research is to design an information system based on the application of blood characteristics testing on platelets to increase the impact of vibration by using a "Blood Shaker Machine" examined through a Haematology Analyzer (HA) and Peripheral Blood Smear (SADT) at any changes in the increase in vibration. Method: The method used in this study is to design an application-based system on the "Blood Shaker Machine" and test the increase in vibration on changes in blood quality both in terms of the number and morphology of the platelets. Result: Significant changes in the morphology of erythrocytes and platelets in the 10 Hz vibration group for 15 minutes also indicated a change in the quality of blood cells, both erythrocytes and platelets.  Conclusion: There is a significant difference in erythrocyte morphology changes between before and after being vibrated at 10 Hz with a p value of 0.014 and There is a significant difference in platelet morphology between before and after being vibrated at 10 Hz with a p value of 0.000.
Testing the Impact of Vibration on Changes in the Number of Erythrocytes and Platelet Counts in Whole Blood Muhamad Syamsul Arif Setiyo Negoro; Jessica Juan Pramudita; Lutfi Rusyadi
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.80-85

Abstract

Blood or plasma is transferred from the unit car to the Blood Donor Unit using a conventional cooler box without any tools to maintain the effect of vibration which is very possible for a decrease in blood quality. Examination carried out to determine the quality of blood through routine hematological examination by counting the number of erythrocytes and platelets. The purpose of this study was to determine the impact of vibration on the number of red blood cells and thrombocytes. The research design was a pre and post test with control group design. The sample size for each group was nine tubes of blood. Data was processed by one way ANOVA and tukeys HSD test. Results There was a significant difference in the number of erythrocytes between the group that was vibrated at a frequency of 11 HZ compared to the group that was vibrated at a frequency of 0 HZ and 5 HZ with p values 0.00 and 0.01, respectively. There was a significant difference in the number of platelets between the groups that were vibrated with a frequency of 11 HZ compared to the groups that were vibrated with a frequency of 0 HZ and 5 HZ with a p value of 0.00. It was concluded that vibrations exceeding 10 Hz could decrease the number of erythrocytes and platelets in whole blood
Co-Authors Agustini Utari Ari Suwondo Bagoes Widjanarko Edy Susanto Lutfi Rusyadi Luthfi Rusyadi M. Munadi Muhamad Syamsul Arif Setiyo Negoro Sultana MH Faradz Tri Indah Winarni