Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Andalas
Aswin Boy Pratama
Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Andalas, Padang 25163, Indonesia
Health Professions Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Cord-Blood and Neonatal BDNF in Early Neurodevelopment: A Systematic Review and Meta-analysis Aswin Boy Pratama; Jamsari Jamsari; Hardisman Hardisman; Eny Yantri
Majalah Kedokteran Andalas Vol. 49 No. 1 (2026): MKA April 2026
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v49.i1.p1-12.2026

Abstract

Objective: To evaluate the association between cord-blood or early neonatal brain-derived neurotrophic factor (BDNF) concentrations and neurodevelopmental outcomes during the first three years of life. Methods: This systematic review and meta-analysis followed PRISMA 2020. PubMed, ScienceDirect, and SpringerLink were searched through September 7, 2026. Human studies measuring BDNF at birth or within the first seven postnatal days and reporting neurodevelopmental outcomes were eligible. Risk of bias was assessed using the Quality In Prognosis Studies tool. Comparable correlation coefficients were Fisher-z transformed and pooled using random-effects inverse-variance models. Results: Of 1,421 records, 14 studies met the inclusion criteria and four contributed to at least one meta-analysis. Associations were small and statistically inconclusive for cognitive development (r=0.17; 95% CI −0.00 to 0.34; I²=0%) and motor development (r=0.13; 95% CI −0.04 to 0.30; I²=0%). The language association was near null (r=0.03; 95% CI −0.14 to 0.21; I²=0%). Seven studies had moderate and seven high overall risk of bias. Conclusion: Neonatal BDNF may carry a modest biological signal for cognitive and motor development, but current evidence is insufficient for clinical prognostic use.
Co-Authors Eny Yantri Hardisman Hardisman Jamsari Jamsari