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All Journal Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research
Destiani, Dika P.
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Medicine & Pharmacology

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Adverse Drug Reaction of Angiotensin Receptor Blockers (Valsartan, Candesartan, Losartan): a Systematic Review Nurviana, Destawesty; Destiani, Dika P.
Pharmacology and Clinical Pharmacy Research Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i3.56906

Abstract

Hypertension is a significant global health problem, with a growing prevalence worldwide. The most commonly documented ADRs of hypertension medication in primary care records include those associated with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). The purpose of this paper is to review and evaluate the potential adverse drug reactions (ADRs) associated with the use of Angiotensin Receptor Blockers (ARBs), specifically valsartan, candesartan, and losartan in the management of hypertension and related diseases. We conducted a systematic review of randomized controlled trial articles that involved valsartan, candesartan, and losartan monotherapy compared with placebo or other standard antihypertensive drugs. PubMed and Google Scholar databases were used in the search for articles in May 2024 and 21 articles were included in this review. This study comprised 21 randomized controlled trials. The study participants' ages ranged from 34.4 years to 76 years. Sample sizes ranged from 16 to 1381 patients with a total 4606 patients. A total of 44 ADRs were observed and the most likely ADRs were headache, dizziness, hypotension, hyperkalemia, nausea, upper respiratory tract infection, and fatigue. Generally, the ADRs that occurred were not fatal and did not lead to discontinuation of therapy. The safety and tolerability profiles of ARBs are among the best for antihypertensive drugs, then overall, the comparison of ARB agents between valsartan, candesartan, and losartan in this class is similar. The most frequent adverse events in the group receiving therapy include headache, dizziness, hypotension, hyperkalemia, nausea, nasopharyngitis, and fatigue. 
Monitoring Pola Peresepan Obat Pasien Usia 0–2 Tahun Menggunakan Indikator WHO Priyadi, Ahmad; Destiani, Dika P.
Indonesian Journal of Clinical Pharmacy Vol 2, No 1 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (800.995 KB)

Abstract

Penelitian ini bertujuan untuk mengevaluasi pola peresepan obat pada pasien usia 0–2 tahun dengan menggunakan lima indikator peresepan berdasarkan guideline World Health Organization yaitu jumlah obat per lembar resep, penggunaan obat generik, Antibiotik, sediaan parenteral, dan obat esensial. Pengumpulan data resep rawat jalan pasien 0–2 tahun diambil secara Retrospektif pada periode Januari–Desember 2012 di salah satu fasilitas kesehatan di Bandung. Dari 2741 lembar resep dengan 6350 obat didalamnya, diperoleh rata-rata jumlah obat per lembar yaitu 2,31 obat per lembar. Penggunaan obat generik sebesar 9,19% dari 6350 obat. Persentase penggunaan antibiotik sebesar 67,53% dan tidak ada penggunaan obat dengan sediaan injeksi dari 2741 lembar resep, sedangkan penggunaan obat esensial sebesar 45,02 % dari 6350 obat yang diresepkan. Dari hasil tersebut dapat dilihat bahwa penggunaan obat generik dan Esensial tergolong rendah sedangkan tingkat penggunaan antibiotik relatif tinggi dibandingkan dengan rekomendasi World Health Organization.Kata kunci: Pola peresepan, obat, WHO Monitoring of Patients Aged 0–2 Years Drug Prescribing  Pattern Used Indicator from WHOThe aim of this study was to evaluate drug used by patients 0–2 years old using five World Health Organization guideline for prescribing indicators, which include average number of drugs per encounter, percentage of drugs prescribed by generic name, percentage of encounters with an antibiotics, injection prescribed, and drugs prescribed from essential drugs list or formulary. Outpatient prescription of patients 0–2 years old period January–Desember 2012 were collected retrospectively in one of health facility in Bandung. Average number of drugs per encounter was gained by dividing 6350 drugs with 2741 prescriptions. Percentage of using generic drugs was 9,19 %, antibiotics were 67,53 % and no injections per encounters, whereas percentage of drugs prescribed from essential drugs list was 45,02 %. The result showed that usage of generic drugs and essential drugs were low while the usage of antibiotics is relatively higher than World Health Organization recommendation.Key words: Prescribing pattern, drug, WHO
Co-Authors Nurviana, Destawesty Priyadi, Ahmad