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Fecal Calprotectin Level of Breast Milk-Formula vs Formula Feeding in Preterm and Low Birth Weight Neonates with Necrotizing Enterocolitis Arisanti, Ditya; Wibowo, Satrio
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.384 KB)

Abstract

Necrotizing enterocolitis (NE) is inflammatory disease and its prevalence was increase in preterm and low birth weight (LBW) neonates. This study was aimed to investigate the differences of fecal calprotectin level in breast milk-formula vs formula feeding infants in preterm and low birth weight neonates with necrotizing enterocolitis. There are 32 preterm and LBW neonates with NE were divided into two group (breast milk-formula and formula only feeding group). Fecal calprotectin level was measured using ELISA method. This study showed that fecal calprotectin level in breast milk-formula feeding group was insignificantly lower as compared to formula feeding group (independent t-test, p = 0.503). Further analysis showed that fecal calprotectin level was negatively correlated with patient’s outcome (Spearman correlation test, p = 0.03, r = 0.512). We concluded that fecal calprotectin level in breast milk-formula feeding group was insignificantly lower as compared to formula feeding only group in preterm and low birth weight neonates diagnosed with necrotizing enterocolitis. There was negative correlation between fecal calprotectin level and patient’s outcome.
Calprotectin and Intestinal Fatty Acid Binding Protein (I-FABP) Level in Preterm Neonates with Necrotizing Enterocolitis Ditya Arisanti; Satrio Wibowo; Soemarno Soemarno
Research Journal of Life Science Vol 6, No 1 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.186 KB) | DOI: 10.21776/ub.rjls.2019.006.01.1

Abstract

Necrotizing enterocolitis (NEC) is inflammatory state of intestinal tissue which mostly occurred in preterm neonates and associated with ischemia and inflammation. This study was aimed to investigate calprotectin level (inflammatory marker) and intestinal fatty acid binding protein (I-FABP) (ischemia marker) in preterm neonates with NEC. This research was designed as cross sectional which involve 32 preterm neonates divided into 2 groups as follows: NEC group (n=16 subjects) and control group (n=16 subjects). Diagnosis of NEC was established by clinical and radiological signs (abdominal distension and pneumatosis). Fecal calprotectin and urinary I-FABP were measured using ELISA method. Results showed that fecal calprotectin and urinary I-FABP was significantly higher in NEC group as compared to control group (Mann-Whitney test, p<0.05). Both calprotectin and I-FABP was positively correlated with NEC state (Spearman correlation test, p=0.000, r=0.866). Moreover, calprotectin and I-FABP level was positively correlated with grade (Bell’s classification) and type (Gordon’s classification) of NEC (Spearman correlation test, p<0.05). We concluded that calprotectin and I-FABP level was higher in NEC group. Moreover, I-FABP but not calprotectin, were correlated with grade and type of NEC.
Fecal Calprotectin Level of Breast Milk-Formula vs Formula Feeding in Preterm and Low Birth Weight Neonates with Necrotizing Enterocolitis Ditya Arisanti; Satrio Wibowo
Journal of Tropical Life Science Vol. 9 No. 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Necrotizing enterocolitis (NE) is inflammatory disease and its prevalence was increase in preterm and low birth weight (LBW) neonates. This study was aimed to investigate the differences of fecal calprotectin level in breast milk-formula vs formula feeding infants in preterm and low birth weight neonates with necrotizing enterocolitis. There are 32 preterm and LBW neonates with NE were divided into two group (breast milk-formula and formula only feeding group). Fecal calprotectin level was measured using ELISA method. This study showed that fecal calprotectin level in breast milk-formula feeding group was insignificantly lower as compared to formula feeding group (independent t-test, p = 0.503). Further analysis showed that fecal calprotectin level was negatively correlated with patient’s outcome (Spearman correlation test, p = 0.03, r = 0.512). We concluded that fecal calprotectin level in breast milk-formula feeding group was insignificantly lower as compared to formula feeding only group in preterm and low birth weight neonates diagnosed with necrotizing enterocolitis. There was negative correlation between fecal calprotectin level and patient’s outcome.
Epilepsy as the Main Clinical Manifestation of Congenital Hypothyroidism: A Rare Case Report Lailita Dwi Cahyanti; Aslin Nur Ainiyah; Zidnal Mafaz; Ditya Arisanti
Magna Neurologica Vol. 3 No. 2 (2025): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i2.2269

Abstract

Background: Congenital hypothyroidism (CH) is defined as a deficiency of thyroid hormones present at birth and is one of the most common causes of intellectual disability. CH shows several manifestations, but it is rarely reported that CH manifests as epilepsy. To our knowledge, this rare manifestation of congenital hypothyroidism has only been reported four times previously. The potential association between CH and epilepsy remains unclear. Case: We reported a rare case of a 1-year-old child who presented to the emergency department with complaints of recurrent seizures. Laboratory results showed increased TSH levels and decreased FT4 levels. Electroencephalography (EEG) results were expected. The patient was diagnosed with epilepsy and congenital hypothyroidism. The patient received stabilization therapy in the ER and was admitted to the PICU for 7 days. During hospitalization and a seven-day evaluation at home, the patient did not experience any further seizures. Discussion: Epilepsy and congenital hypothyroidism can affect each other through three known pathogeneses: mitochondrial dysfunction, oxidative stress, and failure of amino acid regulation in the brain. Long-term use of some anti-epileptic drugs is known to reduce thyroid hormone levels. Conclusion: Thyroid hormones play an essential role in various aspects of epilepsy. Thyroid function screening in patients with epilepsy may be advisable, especially in patients with developmental disorders and relevant symptoms.