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All Journal Bali Journal of Anesthesiology Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Meena, Reema
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Health Professions Medicine & Pharmacology Other

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Clinical profile comparison of cisatracurium and rocuronium in elective surgery Meena, Reema; Jain, Priyanka; Rana, Divya; Verma, Indu; Chauhan, Sunil
Bali Journal of Anesthesiology Vol 3, No 2 (2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.069 KB) | DOI: 10.15562/bjoa.v3i2.140

Abstract

Background:  Most surgeries are carried out with ease using neuromuscular blocking agents. This study was aimed to compare the intubating dose of cisatracurium and rocuronium regarding the onset of action, clinical duration, recovery index, intubating conditions, efficacy, and safety in elective surgery.Method: 60 adult patients of American Society Anesthesiology (ASA) grade I & II, underwent elective laparoscopic surgery were randomized to receive either cisatracurium 0.1 mg/kg (Group C) or rocuronium 0.6 mg/kg (Group R). Neuromuscular monitoring was done using STIMPOD Xavant NMS450. Relaxogram interpretation was carried out for the onset of action, clinical duration, and recovery index.Results: Cisatracurium had significant longer onset (233.33±62.31 vs. 86.66±28.62 seconds, p <0.001) and significant longer clinical duration (40±3.56 vs. 27.46±2.14 minutes, p <0.001) than rocuronium. Recovery index was significantly longer in the cisatracurium group (12.23±1.54 vs. 8.30±1.80 minutes, p <0.001). Clinically acceptable intubating conditions were achieved in 180 seconds (C group) compared to 60 seconds in the R group. No untoward or adverse response and complications were distinguished in either group.Conclusion: Cisatracurium 0.1 mg/kg exhibited a slower onset of action than rocuronium 0.6 mg/kg and provided excellent intubating conditions in the majority of patients after 180 seconds. The clinical duration and recovery index were significantly longer in cisatracurium compared to rocuronium. Both are potent and safe agents with excellent cardiovascular stability.
A Comparison of Postoperative Analgesic Effect of Intravenous Tramadol versus Transdermal Buprenorphine Patch in Patients Undergoing Aortofemoral Graft Surgery Meena, Reema; Sharma, Ashish; Garg, Namita; Yadav, Ramgopal
Indonesian Journal of Anesthesiology and Reanimation Vol. 7 No. 1 (2025): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V7I12025.22-29

Abstract

Introduction: The popularity of the transdermal buprenorphine patch (TDB) is currently increasing for chronic pain management because of its ease of use, non-invasive nature, sustained drug delivery, and avoidance of side effects associated with oral or parenteral routes. However, its role in postoperative pain management for aortofemoral bypass surgery is poorly established. The study was designed to compare the postoperative analgesic effect of intravenous tramadol versus transdermal buprenorphine patch in patients undergoing aortofemoral graft surgery. Objective: To compare the efficacy between a buprenorphine patch versus intravenous tramadol for postoperative analgesia in patients undergoing aortofemoral bypass surgeries.  Methods: This is a hospital-based, prospective, randomized, and interventional study. This study was conducted in the cardiac surgery Operation Theatre (OT). A total of 60 patients of either sex belonging to ASA 2 or 3 in the age group of 30-60 years and BMI ≤ 40 kg/m2 scheduled for aortofemoral bypass surgery were enrolled in this study. These 60 patients were divided into two groups; the intravenous tramadol and the transdermal buprenorphine patch group using a randomization table. Results: The two groups were comparable in terms of demographical data, duration of surgery, and time for extubation. The analysis of variance showed that the VAS score was higher in the buprenorphine group as compared to the tramadol group for the first 3 hours post operatively but after that, the VAS score was significantly less in the buprenorphine group at various study intervals. A greater number of patients complained of pain for the first 3 hours postoperatively, but after that the patients had better pain relief for the rest of the study period. Conclusion: Transdermal buprenorphine applied preoperatively is a safe and effective option for postoperative pain management as it offers superior pain control and reduces the need for rescue analgesia, thereby decreasing potential side effects as compared to intravenous tramadol.
Co-Authors Chauhan, Sunil Garg, Namita Jain, Priyanka Rana, Divya Sharma, Ashish Verma, Indu Yadav, Ramgopal