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All Journal Journal of Biomedicine and Translational Research Diponegoro International Medical Journal (DIMJ)
Mulyantoro, Inu
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience

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Effect of DLBS3233, Metformin, and Their Combination on the Expressions of VEGF and Endometriosis Implants in Endometriosis Mice (A Mouse Model in Endometriosis Study) Wardana, Setya Girindra; Trisetiyono, Yuli; Hadijono, Raden Soerjo; Mulyantoro, Inu; Cahyanti, Ratnasari Dwi; Dewantiningrum, Julian
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.18393

Abstract

Abstract Background: Endometriosis is a gynaecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The process of angiogenesis is regulated by VEGF which plays an important role in the development of endometriosis implants. Metformin is an insulin sensitizer that is known to have a beneficial effect in the treatment of endometriosis and DLBS3233 is a PPARγ agonist, it is hoped that it can reduce VEGF and reduce endometrial implants..Objective: To explore the effect of DLBS3233, metformin, and combination on VEGF expression and endometrial implant area of endometriosis-induced mice.Methods: This experimental study used 3-months old 28 BALB/c mice of endometriosis that were randomly and equally divided into four groups (K, P1, P2, and P3). On the 15th day, the K group was given a placebo, the P1 group was given DLBS3233 0.25 mg/day for 14 days, the P2 group was given metformin 4 mg/day for 14 days and the P3 group was given a combination. The immunohistochemistry of VEGF expression was performed from the abdominal cavity and pelvic peritoneal tissues of the mice and measured by the Remmele Scale Index, while the extracted mice's endometrial implants were analyzed with a computer tracing method. All data normality tests were calculated with the Shapiro-Wilk test. The mean difference test of all groups was analyzed using the one-way ANOVA test and the Kruskal-Wallis test.Results: There were significant differences in the expressions of VEGF (p=0.005) and endometrial implants (p=0.001). Expression of VEGF in the P3 group was significantly lower compared to others and endometrial implant area in the P2 group was significantly lower compared to others.Conclusion: DLBS3233 and Metformin may be a potentially effective drug treatments for endometriosis by decreasing VEGF expression and endometrial implants. Keywords: DLBS3233, Endometriosis, Metformin, VEGF
Vitamin D Levels in Patients with Endometriosis Cysts Mustikarani, Rianti; Mulyantoro, Inu
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.29234

Abstract

Background: Endometriosis is associated with lipid peroxidation by reactive oxygen species (ROS) which causes endometrial cell DNA damage. Vitamin D is known to have good antioxidant content, so it is thought to have the ability to inhibit proliferation, invasion and production of pro-inflammatory cytokines in endometriosis.Objective: To analyze the differences in vitamin D levels between endometriosis cyst patients and normal women and the relationship between vitamin D levels and the size of endometriosis cysts.Methods: Analytical observational study with cross sectional design with 60 samples consisting of 30 endometriosis cyst patients and 30 normal women. Evaluation was carried out on vitamin 25 (OH) D serum levels using the ELISA method and endometriosis cyst size. Cyst size is evaluated by assessing the largest diameter of a single endometriosis cyst assessed through an ultrasound examination by a specialist doctor.Results: Vitamin D levels in the endometriosis group were significantly lower than normal women (13.23 ± 5.39 ng/mL vs 15.83 ± 5.30 ng/mL; p = 0.048). Subjects with vitamin D levels <13.45 had a 4.03x (OR 4.03; CI95% 1.37-11.83) higher risk of experiencing endometriosis compared to subjects with vitamin D levels > 13.45 ng/mL. There was no correlation between vitamin D levels and the size of endometriosis cysts (p=0.720).Conclusion: Endometriosis patients have significantly lower serum vitamin D levels than normal women (OR 4.03; CI95% 1.37-11.83). Serum vitamin D levels do not significantly correlate with endometriosis cyst size.
Co-Authors Hadijono, Raden Soerjo Julian Dewantiningrum Mustikarani, Rianti Ratnasari Dwi Cahyanti, Ratnasari Dwi Wardana, Setya Girindra Yuli Trisetiyono, Yuli