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All Journal Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Murti, Lendy Nugroho Wisnu
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Probiotic Usage as Therapy on Diabetes Mellitus Type II. A Literature Review Murti, Lendy Nugroho Wisnu
Pharmaceutical Journal of Indonesia Vol 4, No 2 (2019)
Publisher : Brawijaya University

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Abstract

A B S T R A C TBackground: Type 2 diabetes has turned into a worldwide medical issue. Probiotic as the microorganisms in the intestinal tract has the potential impact to anticipate the improvement of insulin opposition and glycemic control in patients with type 2 diabetes. This literature review focused on the effects, mechanism of action and potential utilization of probiotic in type 2 diabetes. Results: As therapy in type 2 diabetes, probiotic ready to bring down fasting glucose, HbA1C and HOMA-IR percentage or increment insulin levels. Dicussion: The impact of the probiotic agent acquired on type 2 diabetes through the decrease of lipopolisacharide (LPS), increased  short chain fatty acids (SCFA), inhibition of immune response and oxidative stress, increased  glucagon like peptide-1 (GLP-1), secretion of insulinotropic polypeptides, or increased activity of  glucose transporter-4 (GLUT 4). Conclusion: Probiotic can be a choice to keep up insulin sensitivity and anticipate the beginning of hyperglycemia in type 2 diabetes.
Probiotic Usage as Therapy on Diabetes Mellitus Type II. A Literature Review Murti, Lendy Nugroho Wisnu
Pharmaceutical Journal of Indonesia Vol 4, No 2 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A B S T R A C TBackground: Type 2 diabetes has turned into a worldwide medical issue. Probiotic as the microorganisms in the intestinal tract has the potential impact to anticipate the improvement of insulin opposition and glycemic control in patients with type 2 diabetes. This literature review focused on the effects, mechanism of action and potential utilization of probiotic in type 2 diabetes. Results: As therapy in type 2 diabetes, probiotic ready to bring down fasting glucose, HbA1C and HOMA-IR percentage or increment insulin levels. Dicussion: The impact of the probiotic agent acquired on type 2 diabetes through the decrease of lipopolisacharide (LPS), increased  short chain fatty acids (SCFA), inhibition of immune response and oxidative stress, increased  glucagon like peptide-1 (GLP-1), secretion of insulinotropic polypeptides, or increased activity of  glucose transporter-4 (GLUT 4). Conclusion: Probiotic can be a choice to keep up insulin sensitivity and anticipate the beginning of hyperglycemia in type 2 diabetes.
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