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Synthesis of Alginate/Hydroxyapatite Beads for Acetaminophen Delivery Angan, Anesylvia; Sambudi, Nonni Soraya
Makara Journal of Science Vol. 26, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Conventional drug delivery systems usually involve the intake of multiple drugs, which could amplify the risk of overdosing. Acetaminophen is a widely used pain relief substance that is prone to accidental overdosing. Hence, a controlled drug delivery system is needed to ensure its efficacy. A nanocomposite hydroxyapatite/alginate system that was used as a drug carrier for acetaminophen was synthesized through the sol-gel method, and the mechanism underlying its controlled drug delivery was investigated. Spherical nanocomposite bead samples were synthesized by incorporating 5 wt%, 10 wt%, and 15 wt% hydroxyapatite into mixtures containing alginate. The mixtures were then dropped into calcium chloride solution. The phase purity of the hydroxyapatite sample was confirmed through X-ray diffraction, and the functional groups that confirmed the presence of alginate and hydroxyapatite in the nanocomposite samples were analyzed by using Fourier transform infrared spectroscopy. The release of acetaminophen can be controlled for 48 h, and the Korsmeyer–Peppas kinetics model showed the best correlation for all samples. The kinetics of Al/HAp5, Al/HAp10, and Al/HAp15 were governed by quasi-Fickian diffusion with the n values of 0.199, 0.238, and 0.225, respectively. The composite beads show potential for application as a controlled drug delivery vehicle.
Integrated Project in Separation Process Class as Innovative Tool to Improve Students’ Online Learning Experience Sambudi, Nonni Soraya; Jusoh, Norwahyu; Sapiaa, Nik Abdul Hadi; Ahmad, Syaza Izyanni
Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Vol. 7 No. 1: March 2023
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/esaintika.v7i1.1042

Abstract

Implementation of integrated project in chemical engineering courses has shown positive impact on students’ understanding, teamwork, critical thinking, and communication. In this case, an integrated project covering three different courses in chemical engineering, namely Reaction engineering, Process modelling and simulation, and Separation process was formulated on palm-oil based biodiesel production and introduced to students. The response from questionnaire was recorded and analyzed by using Excel software. More than 90% of students agree that the project helps them to understand the course and prepare for test or exam. While more than 70% of students want to see this type of project for other courses. Majority of students think that collaboration and teamwork help them to finish the project and doing integrated project saves their time to do assessment. Beside improving their soft skill like critical thinking, students can also sharpen their technical skills in solving the problems, especially on process flow drawing, operation of simulation tool, calculation technique, and search for suitable information and data. Through this integrated project, students could explore the connection among courses in Chemical Engineering program and implement the taught concepts in solving engineering problem, which can be challenging things to achieve during online learning.
Treatment of Paracetamol in Water with Different Salinities over Powder and Supported TiO2 and ZnO Photocatalysts Saepurahman, Saepurahman; Mulyani, Gina; Sambudi, Nonni Soraya; Kurniawan, Teguh
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.11017

Abstract

ABSTRACT. Paracetamol's (PCT) Paracetamol's (PCT) presence in water bodies poses a risk to both aquatic life and humans. This study aims to examine the effect of salinities on PCT removal in water using powder and supported photocatalysts. ZnO powder is a superior photocatalyst to TiO2, where the rate constant can be 18 times higher. Salinity boosted the PCT removal up to 2.7 times for TiO2 at lower concentrations but decreased the PCT removal for TiO2 and ZnO at higher values. Immobilizing the powder photocatalysts on a nonwoven polyester support (NPS) dropped the photocatalytic activity, especially for ZnO, whose performance was 36 times lower than its powder counterpart. The passivation of the photocatalysts by the silica binder necessary for attaching the photocatalyst to the support can be linked to the decline in the performance of TiO2 and ZnO composites. The silica and TiO2 formed homogeneous layers on the NPS, unlike the silica and ZnO layers. High salinity reduced the performance of TiO2 composites by 20 times but showed no significant effect on ZnO composites. The performance of the ZnO composite was further reduced when real seawater was used as feed. Keywords: Titanium dioxide, zinc oxide, polyester, paracetamol, salinity.
Improvement of Pitting Corrosion Resistance in Type 201 Stainless Steel by Electrochemical Method in Nitric Acid Solution Hastuty, Sri; Yulia, Fayza; Sambudi, Nonni Soraya; Fauzi, Alfian Kahfi; Nadhor, Fatwa Khoirrun
Jurnal Kimia Sains dan Aplikasi Vol 28, No 4 (2025): Volume 28 Issue 4 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.4.208-214

Abstract

Stainless steel is widely utilized across industries due to its robust resistance to corrosion. Stainless Steel 201 (SS201), characterized by a lower nickel content compared to grade 304, is valued for its cost-effectiveness and strong mechanical properties. However, SS201 is more prone to pitting corrosion in aggressive environments than SS304. This research aims to enhance SS201’s resistance to pitting corrosion through surface treatment involving nitric acid. Cyclic voltammetry was conducted using nitric acid concentrations of 1, 2, and 3 M. The findings indicate that higher concentrations of nitric acid improved corrosion resistance, with 3 M resulting in a pitting depth of 23.667 μm. The application of citric acid contributed to enhanced resistance against pitting corrosion by fostering a chromium-rich surface.
Modification of Polylactic Acid with Eggshell Filler as Biodegradable Composite Sambudi, Nonni Soraya; Radini, Fitri Ayu; Ahmad Kamal, Norashikin; Jusoh, Norwahyu
Journal of Engineering and Technological Sciences Vol. 57 No. 4 (2025): Vol. 57 No. 4 (2025): August
Publisher : Directorate for Research and Community Services, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.eng.technol.sci.2025.57.4.7

Abstract

In this study, polylactic acid (PLA) was proposed as a material for producing bioplastics due to the desirable properties, including high processability, low cost, and good transparency. However, the degradation of PLA as a bioplastic remains a significant challenge. To address this problem, PLA was modified by blending with a bio-filler, in the form of calcium carbonate (CaCO3) prepared from eggshell powder (ESP). The CaCO3 filler in form of ESP was incorporated into PLA using the solution casting method. The parameter being varied was the ESP loading, ranging from 0 wt% to 20 wt%. The results showed that the inclusion of eggshell-derived filler in PLA increased tensile strength and Young’s modulus by 10%, from 24.12 to 26.61 MPa, and 162%, from 3022 to 7932 MPa, respectively. The degradability of composite was done through burial test, which the weight of PLA/ESP-20wt% was decreased by 11.11 wt% after 3 weeks. This suggests that eggshell waste has the potential to serve as an effective filler to improve the mechanical strength and degradation of PLA.