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Rarokar, Nilesh Ramesh
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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Progress in Synthesis of Monoglycerides for Use in Food and Pharmaceuticals Rarokar, Nilesh Ramesh; Menghani, Sunil; Kerzare, Deweshri; Khedekar, Pramod Bhujangrao
Journal of Food and Pharmaceutical Sciences Vol 5, No 2 (2017): J. Food Pharm. Sci (May-August)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.795 KB) | DOI: 10.14499/jfps

Abstract

Glycerides are lipid esters of the glycerol molecule and fatty acids. Their primary function is the storage of energy. Due to its structure and properties, glycerol participates in the formulation or synthesis of many compounds such as food products, cosmetics, pharmaceuticals, liquid detergents. Monoglycerides (MGs) can be formed by both industrial chemical glycerolysis and biological or enzymatic processes. Chemical glycerolysis bring issues of low MGs yield, high operating temperature, formation of undesirable by-products and high energy consumption. On the other hand enzymatic processes have advantages of mild reaction conditions and high purity of MGs. But, several purification steps are required to obtain food or pharmaceutical grade MG, such as neutralization of the reaction media and discoloration followed by expensive molecular distillation. The purpose of this article is to review the main challenges in the synthesis of MGs from triglycerides (TGs) contained in the various fixed oils and application thereof in the food and pharmaceuticals. Keywords:  Catalyzation, glycerolysis, molecular distillation, monoglycerides, solid catalysts.
Investigation of Effect of Extensively Used Polymers on Thermoreversible Properties of Pluronic ® Tri-Block Polymer Rarokar, Nilesh Ramesh; Saoji1, Suprit D; Khedekar, Pramod
Journal of Food and Pharmaceutical Sciences Vol 5, No 3 (2017): J. Food Pharm. Sci (September-December)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (766.919 KB) | DOI: 10.14499/jfps

Abstract

This investigation presents a study on the effect of various polymers on gelling properties of tri-block (Pluronic®) copolymers and increasing the stability parameter of in situ gelling system by altering their composition. The tri-block copolymers finds their importance in fabrication of in situ gelling system for the delivery of various kinds of drugs, which can be administered by topical, ophthalmic or parenteral routes. Pluronic®, is a category of non-toxic, water soluble, biodegradable poly (ethylene oxide)/poly (propylene oxide)/poly ethylene oxide), tri-block copolymers which have application in formulation of various in situ gelling systems. This formulation undergo thermo-reversible gelation, where it exists as a free flowing liquid at low temperature and gels in the range of body temperature to form stable depot in aqueous environment. Gelling system was prepared according to the 'Cold Method' using different concentration of polymers (15% to 20% w/v) and subjected to the determination of gelation temperature (GT), viscosity study and effect of various polymers on the strength of gelation. Overall study on the gelation of system at particular temperature is the important parameter for formulation of in situ drug delivery system. It was established that addition of 0.5% w/v of HPMC K4M into gelling system make it stable for forming gel in the range of body temperature whereas methyl cellulose, carbopol 934P, and HPMC E-5 restrict the gel formation. Key words: Tri-Block Copolymer; Gelation Temperature; Gelling System; Depot.
Co-Authors Kerzare, Deweshri Khedekar, Pramod Khedekar, Pramod Bhujangrao Menghani, Sunil Saoji1, Suprit D