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All Journal Jurnal Cahaya Mandalika Journal Pharmaceutical Science and Application (JPSA)
Sari, Pande Made Nova Armita
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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ANALISIS PENGARUH REBUSAN DAUN KELOR UNTUK MENURUNKAN KADAR GULA DARAH PENDERITA DIABETES MELLITUS TIPE 2 Pangesti, Ni Made Dinda Pradnya; Sari, Pande Made Nova Armita; Devi, Putu Ayu Sri; Rahmasari, Luh Putu Citramas Pradnya; Pratiwi, Ni Komang Angelina Sinta
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 5 No. 2 (2024)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v5i2.2273

Abstract

Diabetes Melitus merupakan sekumpulan gejala gangguan metabolik yang ditandai dengan kadar gula darah di atas normal karena tubuh tidak memproduksi cukup insulin. Penatalaksanaan diabetes melitus dapat dilakukan dengan terapi farmakologi atau terapi non farmakologi yaitu dengan pemberian rebusan daun kelor. Daun kelor dapat digunakan sebagai antioksidan sehingga dapat menurunkan kadar gula darah dalam tubuh. Penelitian ini bertujuan untuk mengetahui pengaruh rebusan daun kelor untuk menurunkan kadar gula darah penderita diabetes melitus tipe 2. Jenis penelitian ini adalah penelusuran pustaka melalui Google Scholar, Researchgate, PubMed, dan situs penyedia artikel ilmiah lainnya. Hasil penelitian menunjukkan adanya pengaruh rebusan daun kelor untuk menurunkan kadar gula dalam darah penderita diabetes mellitus tipe 2. Diharapkan dengan penelitian ini penderita diabetes mellitus dapat menggunakan bahan alami seperti rebusan daun kelor untuk mengontrol kadar gula darah agar tetap normal.
EFFECT OF EXTRACTION METHODS ON TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY POTENTIAL OF ETHANOL EXTRACT OF GALING-GALING LEAVES (Cayratia trifolia (L.) Domin) Suardiana, I Kadek; Putra, A.A. Gede Rai Yadnya; Sari, Pande Made Nova Armita
Journal Pharmaceutical Science and Application Vol. 7 No. 1 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i01.p02

Abstract

Background: Antioxidants play a key role in the prevention and treatment of various diseases. Flavonoids, a class of secondary metabolites, are known for their strong antioxidant properties. Cayratia trifolia (L.) Domin is an Indonesian endemic plant with medicinal potential, particularly as a natural antioxidant source. The extraction process is a critical step in isolating bioactive compounds and must be optimized to maximize flavonoid content and antioxidant activity. Objective: This study aims to evaluate the effect of different extraction methods— maceration, sonication, and Soxhlet extraction—on the total flavonoid content and antioxidant activity of ethanolic extracts of C. trifolia (L.) Domin leaves. Methods: This experimental study used three extraction techniques: maceration, sonication, and Soxhlet extraction. Total flavonoid content was determined using UV-Vis spectrophotometry and expressed as mg quercetin equivalent per gram of extract (mg QE/g extract). Antioxidant activity was measured using the DPPH free radical scavenging assay and expressed as IC₅₀ (ppm). Statistical analysis was conducted using one-way ANOVA with a 95% confidence level. Results: The sonication method yielded the highest total flavonoid content (41.82 ± 0.011 mg QE/g extract) and the strongest antioxidant activity (IC₅₀ = 66.523 ± 0.449 ppm), followed by Soxhlet extraction (35.78 ± 0.01 mg QE/g; IC₅₀ = 84.217 ± 0.565 ppm), and maceration (18.48 ± 0.01 mg QE/g; IC₅₀ = 94.579 ± 1.12 ppm). Statistical analysis showed that the extraction method significantly affected both total flavonoid content and antioxidant activity (P < 0.05). Conclusion: The extraction method significantly influences the yield of total flavonoids and antioxidant activity in C. trifolia ethanolic leaf extracts. Sonication was found to be the most effective method, suggesting its potential use in optimizing the recovery of antioxidant compounds from plant materials. Keywords: Antioxidant Activity; Cayratia trifolia (L.) Domin; DPPH; Extraction methods; Total Flavonoid Contents.
Co-Authors Devi, Putu Ayu Sri Pangesti, Ni Made Dinda Pradnya Pratiwi, Ni Komang Angelina Sinta Putra, A.A. Gede Rai Yadnya Rahmasari, Luh Putu Citramas Pradnya Suardiana, I Kadek