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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Esmady Ariffin, Azrin
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Health Professions Medicine & Pharmacology

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Utilization of Anterior Segment Optical Coherence Tomography Enhanced High Resolution Corneal In Measuring Pterygium Thickness Hilmi, Mohd Radzi; Mohd Kamal, Khairidzan; Che Azemin, Mohd Zulfaezal; Esmady Ariffin, Azrin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): December 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (948.627 KB) | DOI: 10.30659/sainsmed.v9i2.2982

Abstract

Introduction: As various pterygium morphologies have been advocated as contributing factor on corneal astigmatism, little support in the literature available in establishing techniques in measuring pterygium thickness as clinical indicator.Objective: The aim of this study was to describe a quantitative method in determining pterygium thickness using anterior segment optical coherence tomography (AS-OCT).Methods: Anterior segment imaging was performed using enhanced high resolution cornea (EHRC) of Visante™ AS-OCT in 120 primary pterygium eyes. Prior to imaging, corneal topography assessment was performed on each pterygium eye in order to identify its topographic location. Based on topography mapping, three meridians (in degrees) were selected as close as possible to the pterygium border, which signify the demarcation of pterygium from the cornea. Reliability testing between intra and inter-observer of AS-OCT imaging modality was examined using intraclass correlation and scatter plot.Results: The overall (n = 120) mean and standard deviation of pterygium thickness EHRC of AS-OCT modality were 0.48 ± 0.10 mm (confidence interval: 0.45 – 0.50). EHRC of AS-OCT also showed excellent intra and intergrader reliability in measuring pterygium thickness with intraclass correlation of 0.997 (confidence interval: 0.994 – 0.998).Conclusions: EHRC of AS-OCT imaging modality is a better choice in assessing pterygium compared to traditional slit-lamp biomicroscopy. This tool is applicable for future work related to better understanding on the role thickness in pterygium morphology, its progression and prediction of induced corneal astigmatism and visual impairment due to pterygium.
Measurement of Pterygium Tissue Dry Weight Using Two Different Tissue Preparation Techniques in Freeze-Dry Method Hilmi, Mohd Radzi; Mohd Kamal, Khairidzan; Che Azemin, Mohd Zulfaezal; Esmady Ariffin, Azrin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.291 KB) | DOI: 10.30659/sainsmed.v13i2.2958

Abstract

Due to pterygium tissue compression on the corneal surface, it has been hypothesised that the degree of corneal astigmatism caused by pterygium can vary. This study aims to develop a freeze-dried method for estimating net pterygium tissue mass (NPTM) as dry weight. A single surgeon (KMK) excised 60 primary pterygium using the controlled partial avulsion technique and divided them into two groups: formalin-fixed (n=30) and unfixed (n=30). After determining the weight of each sterile container, 5 mL of 5% buffered formaldehyde was added to the formalin-fixed group and stored for one week, while 5 mL of distilled water was added to the non-fixed pterygium group. Each container was pre-frozen for 12 hours before being freeze-dried (-24 hours at -80 degrees Celsius). The result is referred to as the net pterygium tissue mass (NPTM). Using an independent T-test, a comparison of wet and dry weight and percentage of NPTM was conducted between groups. Wet weights for formalin-fixed and non-fixed pterygium were 253.33 82.17 g and 255.17 63.52 g, respectively, while dry weights were 184.92 84.31 g and 179.54 72.85 g. Formalin-fixed pterygium tissue revealed a slightly higher percentage of NPTM than non-fixed pterygium tissue (69.39 13.29% vs. 67.75 13.29%, p = 0.792), but this difference was not statistically significant. The freeze-dried method can be utilised to quantify the NPTM of pterygium fibrovascular tissue and investigate the influence of pterygium translucency on predicting induced-corneal astigmatism.
Co-Authors Che Azemin, Mohd Zulfaezal Hilmi, Mohd Radzi Mohd Kamal, Khairidzan