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All Journal Diponegoro International Medical Journal (DIMJ) Neurona
Hardika, Made Sebastian Dwi Putra
Unknown Affiliation
Health Professions Medicine & Pharmacology Neuroscience

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MALFORMASI KAVERNOSA FRONTAL PADA WANITA BERUSIA 36 TAHUN: SEBUAH LAPORAN KASUS Hardika, Made Sebastian Dwi Putra; Ekasari, Ni Wayan Nurlina; Indrayani, Ida Ayu Sri
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.589

Abstract

Background: Cerebral cavernous malformation (CCM) is a low-flow neurovascular disease caused by dilatation of capillaries in thin-walled cerebral blood vessels, causing extravasation of blood cells, which is the second highest neurovascular disease. It is a dynamic lesion that can develop over time and the current literature until now still discusses ideal management and effective therapeutic interventions. Case Report: A 36-year-old woman, with no previous medical history, experienced her first ever seizure with pattern of focal to generalized motor onset tonic clonic seizure. Initial head computer tomography (CT) imaging results showed a hyperdense lesion with minimal perifocal edema in the left frontal lobe. Digital subtraction angiography (DSA) showed no evidence of arteriovenous malformation or developmental venous anomaly (DVA). She was diagnosed with CCM type I according to the Zabramski classification based on head magnetic resonance imaging (MRI) result. She was given anti-seizure medications and planned for CCM resection as definitive treatment. Discussion: Diagnosis of CCM is quite more difficult than other neurovascular disease. Head MRI imaging serves as the gold standard modality for diagnostic purposes. Treatment for CCM include conservative treatment, surgery, or radiosurgery. Hemorrhagic in multiple lesions, worse initial neurological findings after hemorrhagic episode, brainstem lesion, and concomitant of other vascular malformations are associated with higher morbidity rates. Conclusion: Early detection of CCM can determine the appropriate treatment for patients. Identification of patients at higher risk can optimize the timing of intervention taken so as to reduce morbidity and mortality rates. Keywords: CCM, cavernous, seizure, malformation
Role of Balinese Flute Playing in Enhancing Cognitive Function and Serum Brain-derived Neurotrophic Factor (BDNF) Levels in the Elderly Laksmidewi, Anak Agung Ayu Putri; Mahadewi, Ni Putu Ayu Putri; Arshinta, Lasta; Hardika, Made Sebastian Dwi Putra; Sari, Christine Kathy Putri
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29300

Abstract

Background: Aging is associated with cognitive decline, yet the brain retains adaptive capacity with proper stimulation. Musical activities, including traditional Balinese flute playing, have shown potential in enhancing memory, concentration, and cognitive performance.Objective: This study examined the effect of playing the Balinese flute piece “Morning Happiness” on cognitive improvement in the elderly, as indicated by changes in serum Brain-derived Neurotrophic Factor (BDNF) levels.Methods: This experimental study was conducted from June to September 2024 among elderly participants (>60 years) with controlled risk factors. Subjects were randomized into an intervention group (n=28) and control group (n=14), with a male-to-female ratio of 3:4. The intervention group played the Balinese flute for 20 minutes daily, while the control group listened to the same music for 10 minutes, three times weekly. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina), and serum BDNF levels were measured before and after the intervention.Results: The intervention group showed a significant improvement in total MoCA-Ina scores (Z = -2.82, p = 0.005), particularly in abstraction (Z = -2.296, p = 0.022) and delayed recall (Z = -3.436, p = 0.026). Serum BDNF levels also increased significantly after the intervention (from 5.46 ± 6.16 to 7.63 ± 10.16; p = 0.033), while no significant changes were observed in the control group.Conclusion: Balinese flute playing enhances cognitive function, especially abstraction and memory recall, and increases serum BDNF, supporting its role as a non-pharmacological strategy to promote cognitive health in the elderly.
Co-Authors Anak Agung Ayu Putri Laksmidewi Arshinta, Lasta Ekasari, Ni Wayan Nurlina Ida Ayu Sri Indrayani Mahadewi, Ni Putu Ayu Putri Sari, Christine Kathy Putri