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All Journal The New Ropanasuri Journal of Surgery Jurnal Ilmiah Kesehatan Iqra
Septiman, Septiman
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HUBUNGAN EKSPRESI COX-2 DENGAN SUBTIPE KANKER PAYUDARA Asdar, Asdar; Septiman, Septiman
JIKI Jurnal Ilmiah Kesehatan IQRA Vol 7 No 01 (2019)
Publisher : LPPM STIKES Muhammadiyah Sidrap

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Abstract

Peranan patogenesis COX-2 terhadap pertumbuhan tumor belum jelas dan dapat dilihat dari korelasi perubahan ekspresi COX-2 dengan tingkat proliferasi dan apoptosis serta pertumbuhan tumor. Perubahan ini ditemukan pada respons kemoradiasi, selain itu ada bukti yang menunjukkan bahwa COX-2 menginduksi angiogenesis (in vitro), dan bisa mengurangi fungsi sel-T NK. Ekspresi COX-2 yang berlebihan pada KPD berhubungan dengan kekambuhan, harapan hidup pasien yang pendek dan hasil terapi yang jelek. Dengan melihat protein COX-2 yang berperan pada tumorogenesis KPD di level molekuler, maka hal yang penting data pemeriksaan IHC COX-2 dalam strategi penatalaksanaan serta mengetahui prognosis penderita KPD. Tujuan penelitian ini adalah untuk mengetahui atau menguji hubungsn ekspresi COX-2 dengan subtipe Kanker Payudara. Penelitian ini merupakan penelitian observasional dengan desain cross sectional Hasil penelitian ini menunjukkan tidak terdapat hubungan yang signifikan antara ekspresi COX-2 dengan subtype KPD (p<0,05), dengan persentase tertinggi pada subtype Luminal A (35,7%), sedangkan pada subtype Luminal B, Overekspresi Her-2, dan TNBC didapatkan persentase tertinggi pada pemeriksaaan COX-2 negatif. Diperlukan penelitian longitudinal tentang peranan COX-2 sebagai faktor risiko prognostik pada KPD dan diperlukan penelitian lebih lanjut tentang kontribusi ekspresi COX-2 terhadap grading histopatologi dalam peranannyaterhadap derajat keganasan kanker payudara.
A Rare Presentation of A Giant Epidermal Cyst of The Parietooccipital Region: A Case Reports Kereh, David; Septiman, Septiman
The New Ropanasuri Journal of Surgery
Publisher : UI Scholars Hub

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Introduction. Epidermal cysts are common benign cutaneous cysts. An epidermal cyst may be classified as a giant epidermal cyst if it exceeds 5 cm. Giant epidermal cysts with a diameter of 5 cm or more are rare but have been reported. The epidermal cyst rarely discloses malignancy. Although rare, a case of malignant change of benign epidermal cyst is possible. We describe here a rare case of a giant epidermal cyst of the parietooccipital region in a 35-year-old man. Case Illustration. A 35-year-old man was admitted to the hospital with a huge swelling over the scalp for the past 30 years. The swelling was non-tender, cystic, measuring 18x13x 9 cm, and was situated in the parietooccipital region. Skull CT revealed an oval shape, hypodense mass, well defined, in the parietooccipital scalp with no intra-cranial extension. Complete excision of the lesion was carried out. Excision of redundant skin is needed to achieve good aesthetic results. Histopathological examination showed a thin layer of benign stratified squamous epithelium and lamellated keratin debris present in the cyst. There is no sign of malignant transformation. Conclusions. It can be stated that although epidermal cyst is a slow-growing benign tumor, it can cause diagnostic difficulties when located in the scalp area and when there is a possibility that cranial bones and even intracranial structures are affected by the cyst. CT, MRI or ultrasonography are crucial to determine if the cyst contacts intracranial structures. The histopathology examination should be done to detect malignant transformation.
Co-Authors Asdar Asdar Kereh, David