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Tama, Whisnu Nalendra

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Author-ID : 1357599

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Abnormal electroencephalographyas predictor of mortality in meningoencephalitis Tama, Whisnu Nalendra; Satiti, Sekar; Asmedi, Ahmad
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 1 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Although the incidence of meningoencephalitis has decreased,howeverits mortality remainshigh. Electroencephalography (EEG) has an important role in the management of meningoencephalitis although the imaging modalities have replaced its position. Abnormality in EEG may appear earlier than in imaging so it is expected to predict mortality.The study aimed to investigate the prognostic role of EEG results in predicting mortality of meningoencephalitis.This was an observational prospective cohort study involvingmeningoencephalitis patients in Dr. Sardjito General Hospital,Yogyakartafrom July 2016 to January 2017 who underwent EEG examination.The patients who met the inclusion and exclusion criteria were divided into abnormal and normal EEG groups. The outcomewas the mortality during hospitalization. Furthermore, the type of EEG abnormalities associated with mortality were evaluated.Thirty-eight patients with the mean age was 33.61±20.37 yearwere involved in this study. Twenty-eight patients (73.7%) had abnormal EEG result and 10 patients (26.3%) death.Bivariate analysis showed that abnormal EEG result (p =0.028) and Glasgow Coma Scale (GCS) score (p =0.005) were significantly associated with mortality. Analysis for the type of EEG abnormalities found that only diffuse slowing (p =0.001) was significantly associated with mortality. Multivariate analysis showed either abnormal EEG result or GCS score were independently predictor of mortality. Abnormal EEG and GCS score were interrelated in affecting mortality.In conclusion, abnormal EEG resultin meningoencephalitis, diffuse slowing in particular, is predictor of mortality during hospitalization

PENDEKATAN KLINIS DAN STRATEGI MANAJEMEN TERKINI PADA NYERI PUNGGUNG BAWAH TIPE CAMPURAN Tama, Whisnu Nalendra; Yudiyanta
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.868

Low back pain (LBP) is one of the most common musculoskeletal complaints and a frequent cause of chronic pain. It has a complex etiology which may involve overlapping pain mechanisms, including nociceptive, neuropathic, and nociplastic, resulting in a mixed pain condition. Several studies have shown that neuropathic components are present in a significant proportion of LBP cases, even in the absence of clear radicular symptoms. Understanding the pathophysiological mechanisms underlying mixed pain is essential, including both peripheral and central sensitization processes, as well as interactions between neural and non-neural structures such as the intervertebral disc and facet joints. The clinical approach to LBP requires comprehensive history taking and physical examination, including identification of pain characteristics and red flags, along with the use of neuropathic pain screening questionnaires such as PainDETECT, Douleur Neuropathique en 4 (DN4), and ID Pain. Supporting investigations, including Magnetic Resonance Imaging (MRI) and electrophysiological studies, should be performed as indicated to determine the etiology and degree of nerve involvement. Management of mixed-type LBP should be multimodal, encompassing nonpharmacological therapies such as patient education, medical rehabilitation, and postural correction, as well as pharmacological treatments combining anti-inflammatory and neuropathic pain agents. Although such combination therapy is theoretically beneficial, supporting clinical evidence remains limited and warrants further research. Increasing clinicians’ awareness of the possibility of mixed pain in LBP is crucial for determining more optimal and precise therapeutic strategies to improve patient clinical outcomes. Keywords: low back pain, mixed pain, central sensitization, multimodal management, mechanism-based therapy

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