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All Journal Jurnal Pertahanan : Media Informasi tentang Kajian dan Strategi Pertahanan yang Mengedepankan Identity, Nasionalism dan Integrity Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Faiza, Yaumi
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Medicine & Pharmacology Other

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Pemberian Antitrombotik pada Pasien Acute Limb Ischaemia dengan Cerebral Arteriovenous Malformation (CAM) : Sebuah Laporan Kasus faiza, yaumi; Hawa, Putrya
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 1 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss1.art6

Abstract

Acute Limb Ischaemia (ALI) adalah penurunan mendadak perfusi arteri ekstremitas bawah. Pada pemeriksaan fisik bisa dijumpai hilangnya denyut nadi bagian distal oklusi, kulit dingin dan pucat, penurunan respon sensorik dan kekuatan otot. Cerebral arteriovenous malformation (AVM) merupakan suatu kelainan pada pembuluh darah otak. Keadaan dinding pembuluh darah otak yang terbentuk tidak sebaik dengan pembuluh darah normal sehingga mudah pecah dan menimbulkan masalah intraserebral. Seorang wanita umur 38 tahun datang ke IGD dengan nekrosis setinggi betis kiri dan kelima jari kaki kiri yang dialami sejak 1 minggu sebelum masuk RS. Pasien ini telah dilakukan PTA tanpa stent pada A. Iliaka sinistra (total oklusi), dan pemberian antitrombotik, dan direncanakan amputasi. Pasien menolak untuk amputasi dan menyatakan pulang paksa.
Anopheles Mosquito Gene Editing with CRISPR/Cas9 to Prevent Malaria as an Effort to Help Military Peacekeeping Operations Firmansyah, Hafid Irza; Djatmiko, Christine Bella Putri; Faiza, Yaumi
Jurnal Pertahanan: Media Informasi tentang Kajian dan Strategi Pertahanan yang Mengedepankan Identity, Nasionalism dan Integrity Vol 11, No 3 (2025)
Publisher : The Republic of Indonesia Defense University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33172/jp.v11i3.19533

Abstract

Malaria, caused by Plasmodium transmitted by Anopheles mosquitoes, has a significant global impact, especially in endemic areas where military and peacekeeping forces operate. CRISPR/Cas9 gene editing technology provides hope for reducing the spread of this disease. The focus of this research is on genetic modification of Anopheles mosquitoes by evaluating the potential of CRISPR/Cas9 in preventing malaria transmission in military personnel involved in peace operations. The Anopheles study demonstrated success in mediated knockout of the FREP1 gene, resulting in a reduction in the prevalence of Plasmodium infected mosquitoes. The use of CRISPR techniques provided efficient results with positive impacts on genetic modification, but also demonstrated negative impacts on mosquito fitness, including reduced fecundity and slower pre-adult development. Application of CRISPR/Cas9 to A. gambiae mosquitoes showed a reduction in Plasmodium infection intensity, but with impacts such as lower blood feeding propensity, reduced fecundity, and decreased longevity. Ethical implications need to be considered, including impacts on biodiversity and environmental safety. In implementing CRISPR/Cas9, it is necessary to consider public participation and acceptance, as well as capacity building for fair decisions to effectively address malaria.
Co-Authors Djatmiko, Christine Bella Putri Firmansyah, Hafid Irza Hawa, Putrya