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All Journal Journal of Pharmaceutical Care Anwar Medika Journal Pharmasci (Journal of Pharmacy and Science)
Rochmawati, Ike Dhiah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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EFFECT OF CITICHOLINE CO-ADMINISTRATION WITH ANTIPLATELET IN HOSPITALIZED STROKE ISCHEMIC PATIENTS Rochmawati, Ike Dhiah; Saputra, Dosy Mulia; Rahmawati, Rosy
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 2 No 2 (2020): Volume 2, Nomor 2, Juni 2020
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.259 KB) | DOI: 10.36932/jpcam.v2i2.31

Abstract

Ischaemic stroke is a disease caused by the formation of thrombus or emboli in the cerebral artery. One of the most important medicines which analysed in several studies is Citicholine. The purpose of this study was to look at the effect of adding Citicholine with antiplatelets in Ischemic Stroke patients. The design used was an observational study with a retrospective approach. Patient demographics were analyzed descriptively. From the results of the study found 100 patients used as research samples. Based on the patient's characteristics, the greatest percentage was obtained in female patients, aged> 55 years and with accompanying hypertension, diabetes mellitus. After statistical analysis, there was no difference between the length of stay of patients in different age groups. Citicholine has been shown to provide better outcomes, by looking at the outcomes of patients who are totally cured compared with patients who are partially cured, statistically significant.
Polimorfisme COX-1 terhadap Agregasi Platelet pada Pasien Penyakit Jantung Koroner Wahab, Charliandri Saputra; Putranto, J. Nugroho Eko; Rochmawati, Ike Dhiah
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.203

Abstract

Polimorfisme genetik COX-1 (Cyclooxygenase 1) menjadi salah satu faktor penyebab variasi respon terhadap agregasi platelet. Variasi tersebut dapat menimbulkan Coronary Arthery Disease (CAD) pada pasien penyakit jantung koroner (PJK). Penelitian ini dilakukan di RSUD Sidoarjo di Jawa Timur selama 1 bulan yaitu terhitung mulai bulan November hingga Desember 2017 dengan melibatkan 30 pasien. Metode penelitian yang digunakan yaitu Polymerase Chain Reaction (PCR) agar pemeriksaan polimorfisme COX-1 dan metode Light Transmittance Aggregometry (LTA) untuk pengukuran agregasi platelet. Dari 30 pasien yang terlibat dengan penelitian ini didapatkan jenis polimorfisme COX-1 homozygout (wild type) sebanyak 4 pasien dengan nilai bp pada kisaran rentang 233-243dan Heterozygot sebanyak 26 pasien dengan kisaran rentang 244-294. Analisis yang dilakukan agar mengetahui hubungan antara polimorfisme COX-1 terhadap agregasi platelet pada pasien PJK yaitu analisis inferensial, dimana diperoleh nilai p=0,423. Dari hasil uji analisis yang diperoleh, maka dapat diambil kesimpulan bahwa tidak hubungan antara polimorfisme COX-1 terhadap agrgasi platelet.
Co-Authors Charliandri Saputra Wahab Putranto, J.Nugroho Eko Rahmawati, Rosy Saputra, Dosy Mulia