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All Journal Medula Wellness And Healthy Magazine
Januarti, Ria Wahyu
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Pendekatan deteksi dini non invasif karsinoma nasofaring Januarti, Ria Wahyu
Wellness And Healthy Magazine Vol 2, No 1 (2020): February
Publisher : Universitas Aisyah Pringsewu (UAP) Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (17.202 KB) | DOI: 10.30604/well.57212020

Abstract

Nasopharyngeal carcinoma is a type of cancer that has a considerable prevalence in Indonesia. Nasopharyngeal cancer is associated with Epstein-Barr virus infection, which also correlates with other factors. These factors are age, genetic, environmental and oral hygiene. Usually, nasopharyngeal cancer is late for diagnosis, so it is always found at an advanced stage. In individuals in risky communities, early detection of nasopharyngeal cancer can be done, without being invasive. The examination that can be done is EBV virus serology analysis and EBV DNA examination. The examination can use simple samples such as nasopharyngeal smear and saliva. This convenience allows early detection of nasopharyngeal cancer so that it can reduce morbidity and mortality.
Penggunaan Monoterapi Vs Kombinasi Terapi Antinyeri Dalam Manajemen Nyeri Pascaoperasi Pediatri : Literatur Review Januarti, Ria Wahyu; Irawan, Khadafi
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1760

Abstract

Postoperative pain is an acute sensation accompanied by an inflammatory process related to surgical trauma, which decreases as the tissue heals. However, it is often not well managed after surgery in children. Multimodal analgesia is a key principle for managing acute postoperative pain. One form of multimodal analgesia is combining non-opioid analgesics to reduce postoperative pain and opioid use. The latest guidelines recommend a combination of at least paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) for most types of surgery. NSAIDs and paracetamol have different mechanisms of action, so it can be assumed that combining the two will provide better analgesia than either drug alone. This article was written using the literature review method, which involved searching for literature from various national and international journals. Journal articles from 2015 to 2025 were used as the basis for the articles. The literature search references are from the PubMed, NCBI, and Google Scholar databases. The literature was then analyzed using the systematic literature review method, which included activities such as collecting, evaluating, and comparing the efficacy and acute management post-surgery. Hye-Mi et al.'s research found that the combination of NSAIDs with propacetamol is better postoperative analgesia than opioids. Intravenous administration provides a higher maximum plasma concentration (Cmax) and a shorter time to reach Cmax, resulting in faster and more reliable delivery compared to oral or rectal administration.
Co-Authors Irawan, Khadafi