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All Journal Indonesian Journal of Tropical and Infectious Disease The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Imro'ati, Tri Asih
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Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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Oxidative Stress and the Severity of Gastroesophageal Reflux Disease: Is There Any Correlation? Imro'ati, Tri Asih; Sugihartono, Titong; Widodo, Budi; Nefertiti, Eva Pravitasari; Wibawa, I Dewa Nyoman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/253202445-52

Abstract

Background: Oxidative stress plays a crucial role in the inflammatory response of the oesophageal epithelium; hence, therapies that affect oxidative stress may be a new approach in GERD management.  The objective is to analyze and determine the correlation between Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI) with severity of GERD.Methods: This is an observational analytic study using a cross-sectional design,that  conducted at the Endoscopic Unit of three hospitals in Surabaya, which held from June 2020 to March 2021. The 18 to 60 years old subjects who meet the GERD-Q score 8-18 and not meet the exclusion criteria undergo an endoscopic examination to determine the GERD severity and blood test. Data analysis was using the Spearman rank correlation test.Results: This study indicates that most subjects are women, with mean age 39.31±10.99 years, most are GERD grade A, the mean value of TOS, TAS, ISO respectively is 5.18±1.60, 1.58±0.18, and 3.36±1.35. The laboratory test results show insignificant different based on GERD degree.  There is a non-significant positive correlation between TOS and GERD severity, a significant negative correlation  between TAS and  GERD severity, and a significant positive correlation between OSI and GERD severity (respectively, r = 0.121, p = 0.266 vs r = -0.323, p = 0.044 vs r = 0.345, p = 0.033).Conclusion:  The TAS and OSI may be correlated to the GERD severity but still need further investigations. 
Severe Inflammatory Bowel Disease Manifestations in a Patient with Post-Acute COVID-19 Syndrome (PACS): A Case Report and Literature Review Riswanto, Arival Yanuar; Waskito, Langgeng Agung; Arfijanto, Muhammad Vitanata; Imro'ati, Tri Asih; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol. 14 No. 1 (2026): January - April Edition
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v14i1.78750

Abstract

Post-acute COVID-19 syndrome (PACS) refers to the persistence or recurrence of symptoms lasting more than four weeks after the acute phase of COVID-19. Based on symptom duration, it is classified as subacute symptomatic COVID-19 or long COVID. The interaction between SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) receptor triggers immune system activation, cytokine production, and redistribution of immune cells. Impaired self-tolerance hampers immune reconstitution. In combination with environmental and genetic factors, this dysregulated immune response may act as a potential trigger for autoimmune disease, such as Inflammatory Bowel Disease (IBD). This article aims to describe a possible case of IBD, specifically Crohn’s disease developing as a manifestation of PACS. A 57-year-old male presented with hematemesis, nausea, and decreased appetite four weeks after recovering from COVID-19 infection. Esophagogastroduodenoscopy (EGD) was performed and the results were esophagitis, gastroduodenitis, and multiple lacerations of the gastric corpus. Colonoscopy demonstrated findings consistent with Crohn’s disease, including mucosal ulcerations and segmental inflammation. With supportive therapy and administration of 300 mg of infliximab, 500 mg of mesalazine three times daily, and 125 mg of methylprednisolone intravenously every 24 hours, the patient demonstrated clinical improvement and resolution of bleeding. This case highlights a possible association between PACS and de novo Crohn’s disease, suggesting that post-viral immune dysregulation following COVID-19 may unmask or trigger IBD in predisposed individuals. Clinicians should remain vigilant for gastrointestinal manifestations suggestive of IBD in patients with persistent digestive symptoms after COVID-19 infection, as early recognition and targeted therapy are essential for improving outcomes. 
Co-Authors I Dewa Nyoman Wibawa Muhammad Vitanata Arfijanto, Muhammad Vitanata Nasronudin Nasronudin Nefertiti, Eva Pravitasari Riswanto, Arival Yanuar Titong Sugihartono Ummi Maimunah Waskito, Langgeng Agung Widodo, Budi