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All Journal Al-Manhaj: Jurnal Hukum dan Pranata Sosial Islam Jurnal Farmasi Indonesia Journal of Research in Pharmacy and Pharmaceutical Sciences
Kolib, Abdul
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Religion Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Other

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Journal : Jurnal Farmasi Indonesia

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Brine shrimp lethality test on aqueous extract of Caesalpinia Sappan L. Satya, Nathasya Angelia; Pradana, Dhigna Luthfiyani Citra; Kolib, Abdul; Aprilia, Citra Ayu
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.073 KB) | DOI: 10.35617/jfionline.v13i1.54

Abstract

Caesalpinia sappan L. is a plant in the Fabaceae family and has long been used as a medicinal plant. Caesalpinia sappan L. wood contains active compounds in brazilin, flavonoids, tannins, alkaloids, saponins, and terpenoids, which have antioxidant, anti-inflammatory, antibacterial, antiviral, and anticancer properties. The purpose of this study was to find out the lethal concentration (LC50) in the aqueous extract of Caesalpinia sappan L. wood using the Brine Shrimp Lethality Test (BSLT). LC50 is the concentration value of the compound that causes up to 50% death in Artemia salina Leach. This study used four concentration treatments of 1000 ppm, 500 ppm, 100 ppm, and 50 ppm, and negative control repeated three times. Each concentration and the control negative used 10 Artemia salina Leach larvae. The larval mortality was observed after 24 hours of treatment. An LC50 value of 322.54 ppm indicates an aqueous extract of Caesalpinia sappan L. Therefore, it was moderately toxic in this category.
Co-Authors Aprilia, Citra Ayu Rifkia, Via Satya, Nathasya Angelia Zahra, Rahmanita Kamila