Amelia, Devi Astri Rivera
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Korelasi Antara Indeks Massa Tubuh terhadap Tekanan Darah pada Kelompok Pasien yang Telah Mendapatkan Pengobatan Hipertensi Amelia, Devi Astri Rivera; Kurniawan, Joshua; Nathaniel, Fernando; Firmansyah, Yohanes
MAHESA : Malahayati Health Student Journal Vol 3, No 9 (2023): Volume 3 Nomor 9 (2023)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v3i9.11133

Abstract

ABSTRACT Hypertension and high body mass index (BMI) are risk factors for cardiovascular diseases. Several studies found that blood pressure were rised in high BMI, but studies about correlation of BMI and blood pressure in hypertensive patients on medication are still limited. The study aims to evaluate the correlation between BMI and blood pressure in hypertensive patients on medication.  This quantitative, observational, cross-sectional design study includes all eligible hypertensive patients in outpatient Internal Medicine clinic in Ciawi General Hospital from June to July 2023. A total of 50 patients aged 18 or above are selected by using concecutive sampling. History of hypertension duration and medication was taken from every patients.   The BMI and blood pressure of patients were assessed. Statistical test used in the study is Pearson and Spearman correlation test. Normality of the data is tested with Shapiro Wilk test. The correlation test used in the study is decided based on the normality test result. Significance level expected in the study is 5% (p-value < 0.05). There was a weak correlation (r = 0.314) between body mass index and systolic blood pressure (p-value = 0.026), and a very weak correlation (r = 0.197) between BMI and diastolic blood pressure (p-value = 0.169). The results showed positive but weak correlation between BMI and systolic blood pressure, while there was no significant correlation between BMI and diastolic blood pressure. Keywords : Body Mass Index, Diastolic Blood Pressure, Hypertension, Systolic Blood Pressure  ABSTRAK Hipertensi dan indeks massa tubuh (IMT) merupakan faktor risiko terjadinya penyakit kardiovaskular. Beberapa penelitian menunjukkan bahwa tekanan darah akan meningkat pada orang dengan IMT tinggi, namun penelitian mengenai hubungan indeks massa tubuh dengan tekanan darah pada pasien hipertensi dalam pengobatan masih terbatas.  Untuk mengevaluasi korelasi antara IMT dan tekanan darah pada kelompok pasien hipertensi yang sedang mendapatkan pengobatan. Penelitian ini merupakan penelitian kuantitatif, observasional, dengan desain potong lintang. Penelitian ini dilaksanakan di Poliklinik Penyakit Dalam RSUD Ciawi pada Periode Juni hingga Juli 2023. Pemilihan sampel dilakukan secara berurutan pada 50 pasien usia > 18 tahun yang telah terdiagnosis penyakit hipertensi dan telah mendapatkan obat hipertensi, yang memenuhi kriteria inklusi dan eksklusi. Analisa statistik yang digunakan dalam penelitian ini berupa uji korelasi Pearson dan Spearman. Penentuan uji normalitas atau sebaran data pada penelitian ini menggunakan uji Shapiro Wilk. Penentuan uji korelasi didasarkan pada interpretasi uji normalitas. Interpretasi nilai korelasi didasarkan pada nilai r-correlation (r). Nilai kemaknaan yang diharapkan pada penelitian ini adalah sebesar 5% (p-value < 0,05). Didapatkan korelasi positif yang lemah (r = 0,314) antara indeks massa tubuh dengan tekanan darah sistolik (p-value = 0,026), dan korelasi yang sangat lemah (r = 0,197) antara IMT dengan tekanan darah diastolik (p-value = 0,169). Korelasi antara IMT dan tekanan darah sistolik positif namun lemah, sedangkan korelasi antara IMT dan tekanan darah diastolik tidak signifikan. Kata Kunci: Hipertensi, Indeks Massa Tubuh, Tekanan Darah Diastolik, Tekanan Darah Sistolik
The Impacts of Intravesical Bacillus Calmette–Guérin (BCG) Therapy on Male Fertility in Non-Muscle-Invasive Bladder Cancer (NMIBC): A Narrative Review Putra, Rosadi; Amelia, Devi Astri Rivera
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 2 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i2.678

Abstract

Background: Intravesical Bacillus Calmette–Guérin (BCG) is the current gold standard adjuvant therapy to reduce both recurrence and progression of non-muscle-invasive bladder cancer (NMIBC). On the other hand, there is a growing concern about its possible effect on male fertility. Objective: This narrative review provides an analysis of the recent evidence regarding the impact of intravesical BCG therapy on semen quality and overall male fertility parameters in reproductive-age NMIBC patients. Methods: A targeted literature review was performed for prospective clinical studies assessing semen parameters and reproductive hormones before and after intravesical therapy. A narrative review was conducted that included studies eligible for inclusion (up to date through October 2023) to describe comparative changes in semen quality and endocrine function by comparing BCG-treated men with matched cohorts following exposure. Results: Intravesical BCG was associated with decreased sperm concentration and motility, in some cases with progression to oligospermia and abnormal sperm morphology including "amorphous" heads, bent necks, and short tails—although results were inconsistent. Although early studies found stable hormonal profiles, recent data have shown increases in follicle-stimulating hormone and testosterone, indicating testicular stress with compensatory feedback mechanisms. Conversely, no adverse reproductive effects were observed with mitomycin C. Conclusions: Intravesical BCG may transiently interfere with spermatogenesis while endocrine function remains intact. These results underline the importance of fertility counseling and semen cryopreservation before intravesical therapy. This needs to be confirmed in larger studies with longer follow-up periods for reproductive outcomes.