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All Journal Journal of Research and Technology Jurnal Midpro Community Empowerment Journal Pharmasci (Journal of Pharmacy and Science) Acta Holistica Pharmaciana
Handrianto, Prasetyo
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences Other

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ANALISIS KADAR KALSIUM OKSALAT PADA TEPUNG PORANG SETELAH PERLAKUAN PERENDAMAN DALAM LARUTAN ASAM (ANALISIS DENGAN METODE TITRASI PERMANGANOMETRI) Wardani, Ratih Kusuma; Handrianto, Prasetyo
Journal of Research and Technology Vol 5, No 2 (2019)
Publisher : Universitas Nahdlatul Ulama Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tubers included in the family Araceae contain a lot of calcium oxalate. High calcium oxalate consumption in the body can cause health problems. One of these examples is in the kidneys. Tubers with high levels of calcium oxalate, if immersed in acidic solutions, calcium oxalate levels can be reduced. In this research, immersion of porang flour in starfruit juice, lime juice and vinegar with the aim that the calcium oxalate content contained in it can be reduced. Calcium oxalate levels were analyzed by permanganometric titration method. The results of this study indicate that acidic solutions can reduce calcium oxalate levels in porang flour. Calcium oxalate levels were analyzed by permanganometric titration method. The results of this study indicate that acid solution can reduce calcium oxalate levels in porang flour. The 7% Averrhoa bilimbi juice solution was able to reduce calcium oxalate levels by 62.68%. The 5% lime juice solution gives better results than the Averrhoa bilimbi juice solution. The 5% lime juice solution can reduce calcium oxalate levels by 65.94%. The biggest decrease in calcium oxalate levels was shown in porang flour after soaking it with 20% vinegar acid solution, which amounted to 90.27%.
Aktivitas Antibakteri Ekstrak Jamur Lingzhi (Ganoderma lucidum) Menggunakan Pelarut Etanol terhadap Escherichia coli. Handrianto, Prasetyo
Journal of Pharmacy and Science Vol. 2 No. 1 (2017): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v2i1.64

Abstract

ABSTRAKJamur Lingzhi (Ganoderma lucidum) merupakan herbal yang memiliki aktivitas antibiotik atau antibakteri. Triterpenoid dalam Jamur Lingzhi mengandung senyawa yang menunjukkan aktivitas antibakteri melaluimekanisme pengikatan polimer yang kuat terhadap porin (protein transmembran) pada membran luar dari dinding sel bakteri sehingga menyebabkan kerusakan pada porin. Tujuan penelitian ini adalah menentukan efek ekstrak etanol Jamur Lingzhi dalam menghambat pertumbuhan bakteri Escherichia coli. Metode yang digunakan adalah metode cakram dengan mengamati zona hambat yang muncul disekitar cakram. Kosentrasi ekstrak yang digunakan adalah 20 µg / ml, 40 µg / ml, 60 µg / ml, 80 µg / ml, 100 µg / ml. Kosentrasi ekstrak 20µg / ml dan 40 µg / ml menghasilkan zona hambat masing-masing 10,5 mm dan 12,4 mm yang dikategorikan sebagai kurang aktif, sedangkan kosentrasi 60 µg / ml, 80 µg / ml, dan 100 µg / ml menghasilkan zona hambat 13,65 mm, 14,9 mm, dan 16,5 mm yang dikategorikan sebagai aktif. Hasil menunjukkan ekstrak etanol Jamur Lingzhi dapat  menghambat pertumbuhan bakteri Escherichia coli.Kata kunci : Ganoderma lucidum, Escherichia coli, Ekstrak etanol, Antibakteri.ABSTRACTLingzhi mushroom (Ganoderma lucidum) is a herbal remedy that has as an antibiotic or antibacterial activity. Lingzhi mushroom triterpenoids containing compounds which possess antibacterial activity by reacting with porin mechanisms (transmembrane protein) on the outer membrane of the bacterial cell wall, forming a strong bond polymers that cause damage porin. The purpose of this study was to was to determine the effect of Lingzhi mushroom extract (Ganoderma lucidum) using ethanol in inhibiting the growth of bacteria Escherichia coli. The method used was paper disc method by observing the clear zone that is visible around the paper disc. And concentration used was 20 µg / ml, 40 µg / ml, 60 µg / ml, 80 µg / ml, 100 µg / ml. At a concentration of 20 µg /ml and 40 µg / ml produce inhibition zone of 10.5 mm and 12.4 mm by category inhibition zone less active and at a concentration of 60 µg / ml, 80 µg / ml, 100 µg / ml produce inhibition zone 13.65 mm by 14.9 mm and 16.5 mm in the active category. The results obtained show that the extract of lingzhi mushroom (Ganoderma lucidum) using ethanol effect on the growth of the bacterium Escherichia coli.Keywords: Ganoderma lucidum , Escherichia coli, Ethanol extract, Antibacterial.
Preventing the spread of Covid-19 through the habit of proper washing hands for madrasah diniyah students Fajrin, Fitriana Ikhtiarinawati; Handrianto, Prasetyo; Khusna, Naila Shofa Nida’ul
Community Empowerment Vol 6 No 7 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.607 KB) | DOI: 10.31603/ce.4922

Abstract

Covid-19 has become a global pandemic and affects all ages, including children. This service activity is intended to prevent the spread of Covid-19 for madrasah diniyah students. This service was carried out through health education, both lectures and demonstrations. The results of this activity revealed that the habit of proper hand washing can be instilled through the delivery of information about the importance of hand washing, 6 steps of proper hand washing, and the practice of washing hands in groups and independently.
Effect of White Oyster Mushroom (Pleurotus ostreatus) Ethanol Extract on Bacillus subtilis Bacteria Handrianto, Prasetyo; Ratnasari, Evy
Jurnal MIDPRO Vol 13 No 2 (2021): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v13i2.342

Abstract

The increasing number of infectious diseases caused by bacteria, fungi, viruses and parasites in Indonesia, and one of the bacteria that causes this disease is Bacillus subtilis. Therefore, the role of antibacterial is very important for the treatment of this disease. One of the antibacterials from nature is the white oyster mushroom (Pleurotus ostreatus). The purpose of this study was to determine the effect of various concentrations of white oyster mushroom (Pleurotus ostreatus) extract which was effective as an antibacterial against Bacillus subtilis. The research method uses the paper disc diffusion method. The results showed that the bacterial inhibition zone at a concentration of 20 g/ml obtained an average of 9.5 mm in the medium category, a concentration of 40 g/ml obtained an average of 11.3 mm in the strong category, a concentration of 60 g/ml obtained an average of 13, 3 mm in the strong category, a concentration of 80 g/ml obtained an average of 15.5 mm in the strong category and a concentration of 100 g/ml obtained an average of 17.3 mm in the strong category. The conclusion of this research is white oyster mushroom can be used as an anti-bacterial for Bacillus subtilis.
UJI ANTIBAKTERI EKSTRAK JAHE MERAH Zingiber officinale var. Rubrum TERHADAP Staphylococcus aureus DAN Escherichia coli Handrianto, Prasetyo
Journal of Research and Technology Vol. 2 No. 1 (2016): JRT Volume 2 No 1 Jun 2016
Publisher : 2477 - 6165

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55732/jrt.v2i1.259

Abstract

The study of inhibition testing antibacterial extract Fresh Red Ginger Zingiber officinale var. Rubrum Against Staphylococcus aureus, and Escherichia coliguna to determine the source of antibacterial natural products, especially red ginger has been conducted. Anti-bacterial inhibition test using disc diffusion method with fresh red ginger rhizome material. The study was conducted using concentrations: 0%, 20%, 40%, 60%, 80%, and 100%. Concentration of 0% was used as a negative control. The data obtained will be tested statistically using ANOVA with sig. 0.05. The results showed that the extraction of fresh red ginger (Zingiber officinale var. Rubrum) at a concentration of 100% has the highest inhibitory region to S. aureus (15.83 mm)and E. coli (14:22 mm). It can be concluded that the extract of fresh red ginger Zingiber officinale var. Rubrum at a concentration of 100% has a moderate level of inhibition to S. aureus and weak level of inhibition to E. coli. Keywords: Escherichia coli, Fresh red ginger extract of Zingiber officinale var. Rubrum, Staphylococcus aureus.
Activity Of Lingzhi Fungan Ethanol Extract (Ganoderma Lucidum) Using Soxhlet Method For Bacteria Propionibacterium Acnes Handrianto, Prasetyo
Jurnal Midpro Vol. 12 No. 1 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i1.220

Abstract

The purpose of this study is to know Lingzhi Mushroom extract (Ganoderma Lucidum) has antimicrobial activity against Propionibacterium acnes using Ethanol Solvent, the method used is the disc diffusion method using 6 repetitions, the concentration used is 20 µg / ml, 40 µg / ml, 60 µg / ml / ml, 80 µg / ml and 100 µg / ml, Lingzhi mushroom was extracted using ethanol solvent with the Soxhlet method. The results of the research data showed that the largest inhibitory zone was shown at a concentration of 100 µg / ml of 6.91 mm with a medium inhibitory category. The conclusion of this research is the Lingzhi mushroom is able to inhibit the activity of Propionibacterium acnes in the medium category.
Aktivitas Antibakteri Jamur Lingzhi Terhadap Bakteri Salmonella typhi: A Literature Review Viantika, Sindy Indra; Solihah, Hadi Rotus; Smith, Zakinah; Avriani, Rahma Dita; Dewi, Lela Kumala Sari; Hasanah, Maulidya; Pratiwi, Ajeng; Ramadhani, Dea Silvia; Andini, Atika Wahyu; Azaria, Amira Zanuba; Handrianto, Prasetyo
Acta Holistica Pharmaciana Vol 5 No 1 (2023): Acta Holistica Pharmaciana
Publisher : School of Pharmacy Mahaganesha (Sekolah Tinggi Farmasi Mahaganesha)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62857/ahp.v5i1.103

Abstract

Indonesia merupakan negara dengan keanekaragaman hayati yang sangat tinggi. Negara Indonesia memiliki tanah yang subur karena letak geografisnya yang berada di kawasan tropis, sehingga memiliki banyak hasil pertanian, salah satunya adalah tumbuhan jamur. Ganoderma lucidum merupakan jamur yang banyak digunakan untuk penelitian baik dari segi aktivitas biologis maupun efek farmakologisnya Ganoderma lucidum adalah sumber yang sangat berharga dari zat aktif biologis yang dapat digunakan sebagai antibakteri atau antimikroba. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri Ganoderma lucidum terhadap bakteri Salmonella typhi dengan berbagai macam pelarut pada metode difusi cakram. Desain penelitian ini adalah literature review. Peneliti melakukan pencarian naskah melalui database resmi dan sumber pustaka yang relevan dengan topik penelitian. Jumlah artikel yang diresume adalah 3 artikel nasional dan 2 artikel internasional. Berdasarkan hasil resume ke lima artikel tersebut diketahui bahwa ekstrak jamur lingzhi (Ganoderma lucidum) dapat menghambat pertumbuhan bakteri Salmonella sp. Zona hambat terbesar dengan kategori kuat sebesar 20.60 mm diperoleh dengan menggunakan metode uji antibakteri difusi kertas cakram. Metode ekstraksi yang digunakan adalah soxhletasi dengan konsentrasi ekstrak 40μg/ml dan menggunakan pelarut aseton. Zona hambat terkecil kategori sangat lemah sebesar 0 mm diperoleh dengan konsentrasi ekstrak 50mg/ml yang menggunakan metode difusi kertas cakram dan pelarut etilasetat. Perlu dilakukan pengujian ulang untuk membandingkan aktivitas antibakteri ekstrak Ganoderma lucidum terhadap bakteri Salmonella typhi dengan jenis pelarut dan konsentrasi yang berbeda.
Co-Authors Ajeng Pratiwi Andini, Atika Wahyu Avriani, Rahma Dita Azaria, Amira Zanuba Dewi, Lela Kumala Sari Fajrin, Fitriana Ikhtiarinawati Hasanah, Maulidya Khusna, Naila Shofa Nida’ul Ramadhani, Dea Silvia Ratih Kusuma Wardani Ratnasari, Evy Smith, Zakinah Solihah, Hadi Rotus Viantika, Sindy Indra