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All Journal JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASIMED (JFM)
Sumirtapura, Yeyet Cahyati
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Optimasi Nanoemulsi Natrium Askorbil Fosfat melalui Pendekatan Design of Experiment (Metode Box Behnken) Nursal, Fith Khaira; Sumirtapura, Yeyet Cahyati; Suciati, Tri; Kartasasmita, Rahmana Emran
JSFK (Jurnal Sains Farmasi & Klinis) Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.3.228-236.2019

Abstract

Penghantaran senyawa hidrofilik secara transkutan memiliki keterbatasan karena permeabilitas rendah sehingga sulit dalam menembus lapisan stratum corneum (SC). Natrium askorbil fosfat (NAF) merupakan salah satu senyawa turunan vitamin C yang sangat hidrofil dan permeabilitas rendah terhadap lapisan kulit. Sebagaimana vitamin C, NAF dapat berfungsi sebagai antioksidan juga memiliki aktivitas sebagai antikerut karena dapat memicu pertumbuhan kolagen pada fibroblast. NAF dibuat dalam nanoemulsi, karena sediaan dengan ukuran globul yang kecil diharapkan dapat menembus lapisan SC dan membawa zat aktif berpenetrasi ke dalam lapisan kulit. Optimasi formulasi nanoemulsi dilakukan melalui pendekatan statistik design of experiment (DoE) yang terdiri dari desain faktorial dan respon surface methods (RSM hingga diperoleh hasil yang lebih efektif dan efisien. Komposisi minyak (VCO), surfaktan (Tween 80), ko surfaktan (PEG 400) dan proses pengadukan (waktu dan kecepatan) merupakan faktor yang berperan dalam optimasi formulasi. Penentuan faktor tersebut melalui desain eksperimen 2 level factorial dan dilanjutkan dengan metode Box Behnken menggunakan perangkat lunak Minitab 17. Parameter yang diamati adalah ukuran globul dan indeks polidispersitas. Berdasarkan hasil optimasi diperoleh nilai VCO 10% dan kombinasi surfaktan 24%, waktu dan kecepatan pengadukan 5 menit, 200 rpm memberikan ukuran globul ±180 nm dan indeks polidispersitas dibawah 0,5. 
The Effect of Variation in Polyvinylpyrrolidone (PVP) Concentration as a Binder in The Formulation of Curcumin Isolate Lozenges Putri, Yola Desnera; Dewantara, Annisa Putri; Sumirtapura, Yeyet Cahyati; Andriyannto, Adit
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tqs16n98

Abstract

Background: The pharmaceutical industry continues to develop user-friendly dosage forms to improve patient compliance, especially for individuals who have difficulty swallowing conventional tablets. Lozenges are an alternative oral dosage form that does not require water and allows drug absorption through the oral mucosa, making them more practical and convenient. In lozenge formulation, polyvinylpyrrolidone (PVP) as a binder plays an important role in determining physical characteristics such as hardness, friability, and disintegration time. Objective: This study aimed to evaluate the effect of varying PVP concentrations on the physical characteristics of curcumin isolate lozenges and to determine the optimal formulation. Methods: An experimental method using wet granulation was applied with PVP concentrations of 1%; 2%; 3%; 4% and 5%. Evaluations included granule properties (moisture content, flow rate, angle of repose, compressibility index) and tablet properties (organoleptic characteristics, weight and size uniformity, hardness, friability, and disintegration time). Results: Increasing PVP concentration influenced tablet characteristics, particularly hardness, friability, and disintegration time. All formulations met the physical quality requirements for lozenges. The formulation containing 3% PVP showed the most balanced characteristics compared to others. Conclusion: PVP concentration affects the physical properties of curcumin lozenges, with 3% identified as the optimal concentration, indicating its potential as a practical alternative oral dosage form.
Co-Authors Andriyannto, Adit Dewantara, Annisa Putri Fith Khaira Nursal Rahmana Emran Kartasasmita Tri Suciati Yola Desnera Putri