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Tjipto, Bambang W
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Medicine & Pharmacology Public Health

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A Study Of The Effect Of Olive (Olea Europaea) Stem Methanol Extract As An Antibacterial Against Staphylococcus Aureus Bacteria Raharja, Davin; Dewi, Bernadette DN; Tjipto, Bambang W
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 2 (2020): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.456 KB) | DOI: 10.33508/jwmj.v2i2.2477

Abstract

Introduction: Herbal medicine is starting to become an alternative to treating various diseases. Based on proven research, olive plants (Olea europaea) have the potential to inhibit the growth of bacteria that causes infections. Drugs to treat bacterial infections are antibiotics, and high exposure to antibiotics could increase the possibility of resistance. At the end of the 1940s, it was shown that 28% of the Staphylococcus aureus (S. aureus) bacteria were already resistant to penicillin. Several classes of antibiotics have been created to deal with S. aureus infections. Still, these bacteria show their unique ability to respond quickly to some of the new antibiotics in producing resistance effect. That is why we need another alternative to overcome infections caused by these bacteria. Aim: The purpose of this study is to know the effect of olive (Olea europaea) stem methanol extract as an antibacterial against Staphylococcus aureus bacteria. Methods: This study uses an experimental study with the broth microdilution method, using extract concentrations of 200-51.200 µg/mL. Minimum Inhibitory Concentration (MIC) values were obtained from the results of spectrophotometer reading, and Minimum Bactericidal Concentration (MBC) was obtained from the results of streaking on agar media. Result: In this study the MIC value at a concentration of 200-51.200 µg/mL could not be evaluated because it showed no linear lines, and the MBC value was not found. But there was a reduction in the number of colonies at a concentration of 51.200 µg/mL by approximately 50%. Conclusion: Methanol extract of olive stems proved to have no antibacterial effect against Staphylococcus aureus bacteria at concentrations of 200-51.200 µg/mL.
The Potential Diuretic Comparison Between Parts Of Cucumber (Cucumis Sativus L.) In Male Mus Musculus Vincensa, Elicia; Tjipto, Bambang W; Novita, Bernadette D
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 1 (2021): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i1.3006

Abstract

ntroduction : Cardiovascular diseases are one of the most common cause of death inIndonesia. One kind of cardiovascular event is hypertension. Hypertension is a type ofCardiovascular Disease which incidence rate is predicted to increase in the year of 2025.Diuretic is one of the therapies that can be used for this disease. Diuretic works by decreasingblood volume by managing water and sodium balance inside the body. This effect can beobtained from Cucumber (Cucumis sativus L.). Purpose : The aim of this study is to explain the differences in potential diuretic effect amongparts of Cucumber (Cucumis sativus L.). Method : This study use post-test only control group design method in animal subject(invivo). Animal subjects in this study were 44 male Mus musculus. the animals were dividedinto 9 treatment groups and 2 control groups. All Mus musculus get 1 mL methanol extract ofCucumber (Cucumis sativus L.) according to their group. The animals were put in metaboliccage to measure urine volume for 24 hours. Results : Part of Cucumber (Cucumis sativus L.) that has the best potential diuretic were theflesh and rind on 0,5 mg/mL. Part of Cucumber (Cucumis sativus L.) that has the highestnatriuresis and kaliuresis was whole fruit (flesh, rind, and seed). Conclusion : Cucumber (Cucumis sativus L.) has a similar potential diuretic with Furosemid.Low concentrations lead to better potential diuretic. Natriuresis and Kaliuresis can also befound on Cucumber (Cucumis sativus L.).
Co-Authors Dewi, Bernadette DN Novita, Bernadette D Raharja, Davin Vincensa, Elicia