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All Journal Jurnal Kesehatan Prosiding University Research Colloquium
Wabula, Mega Berkah Mustika
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Humanities Computer Science & IT Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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AKTIVITAS LACTOBACILLUS PLANTARUM ISOLAT AIR SUSU IBU PADA TIKUS GALUR WISTAR DIABETES MELLITUS Kartikasari, Oktavia; Astuti, Anggun Dian; Wabula, Mega Berkah Mustika; Dewi, Sri Sinto
Jurnal Kesehatan Vol 10, No 3 (2019): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (710.295 KB) | DOI: 10.26630/jk.v10i3.1488

Abstract

Lactobacillus plantarum is a Lactic Acid Bacteria (LAB) that has the potential to be used as a probiotic agent. Probiotics are antidiabetic because they can inhibit alpha-glucosidase enzymes. This study aims to was to determine the antidiabetic effects of probiotic Lactobacillus plantarum isolates of breast milk (ASI). The study was conducted at the Microbiology Laboratory of the University of Muhammadiyah Semarang and the Pharmacology Laboratory of the Semarang College of Pharmacy during the month of April-June. Experimental research with 25 male wistar mice was divided into 5 groups (K-, K+, P1, P2, P3) Alloxan monohydrate induction was carried out intraperitoneally at a dose of 150mg/kg BW. Fasting blood glucose measurements were performed at baseline (before alloxan induction), post alloxan and at the end of treatment. Diabetic mice fasting blood glucose levels shouldbe± 200 mg/dL. Suspension of Lactobacillus plantarum isolate ASI was carried out orally for 7 days. Based on the ANOVA test there were significant differences in the decrease in blood glucose with a significant value of p-value=0,009<0,05. Based on the Tuckey post hoc test treatment group P1, P2, P3 there were no significant differences between treatment groups even though the dosage was different. 1 time a day treatment is an efficient dose in reducing blood glucose.
Antibakteri Kombinasi Ekstrak Binahong dengan Antibiotik Meropenem terhadap MDRPA Penyebab HAIs Rahmasari, Galuh Dwi Mustika; Noer, Anashirul Ishlah; Wabula, Mega Berkah Mustika; Sadiq, Alfian La Ode; Kartika, Aprilia Indra
Prosiding University Research Colloquium Proceeding of The 10th University Research Colloquium 2019: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Infeksi nosokomial atau Healthcrae Assicated Infection(HAIs) banyak yang disebabkan oleh bakteri patogen nosocomial Pseudomonas aeruginosa. Angka infeksi nosocomial yang disebabkan oleh bakteri ini 10%-20% pada unit ICU, biasanya terjadi pada pasien septicemia, sistik fibrosis, luka bakar dan luka infeksi. Infeksi Pseudomonas aeruginosa dapat diobati dengan antibiotic yaitu dengan antibiotic meropenem. Tanaman Binahong (Anredera cordifolia(Ten) Steeins) adalah salah satu tanaman yang secara empiris digunakan sebagai obat antibakteri. Penelitian ini bertujuan untuk mengkombinasikan antara antibiotic meropenem dan ekstrak daun binahong dalam menghambat pertumbuhan bakteri Pseudomonas aeruginosa. Metode penelitian ini menggunakan desain eksperimental dan metode uji daya hambat bakteri menggunakan uji difusi agar. Hasil uji kombinasi ekstrak binahong pada konsentrasi 20% memiliki zona hambat dengan rata-rata 39mm sedangkan perlakuan antibiotik tanpa kombinasi memiliki rata-rata zona hambat 36mm. Kombinasi ekstrak binahong konsentrasii 20% dengan antibiotik meropenem dapat menghambat bakteri Pseudomonas aeruginosa dengan daya hambat lebih besar dari penggunaan antibiotic tanpa kombinasi ekstrak binahong.
Co-Authors Aprilia Indra Kartika, Aprilia Indra Astuti, Anggun Dian Kartikasari, Oktavia Noer, Anashirul Ishlah Rahmasari, Galuh Dwi Mustika Sadiq, Alfian La Ode Sri Sinto Dewi