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Anum Mohd Yusof, Yasmin
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Medicine & Pharmacology

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CYTOTOXICITY AND ANTIOXIDANT ACTIVITY OF ZINGIBER OFFICINALE AND 6-GINGEROL ON HEPG2 CELLS Hanif, Harliansyah; Azian Murad, Noor; Wan Ngah, Wan Zurinah; Anum Mohd Yusof, Yasmin
Jurnal Kedokteran YARSI Vol 16, No 1 (2008): JANUARI - APRIL 2008
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.269 KB) | DOI: 10.33476/jky.v16i1.218

Abstract

The present study was designed to compare the effects of ethanolic extract of ginger (Zingiber officinale) and its phenolic component [6]-Gingerol on viability, antiproliferation and apoptotic levels of human hepatoma cell lines (HepG2) and its antioxidant activity. HepG2 cells were cultured in Eagle?s minimum essential medium (EMEM) and the percentage of cell cytotoxicity was evaluated by tetrazolium salt (MTS) assay. Antiproliferation and apoptotic levels were measured by 5?Bromo-2?deoxyuridine (BrdU) colorimetry. Antioxidant capacity was studied by 1.1-diphenyl-2-picryl-hydrazyl radical (DPPH) using spectrophotometry. We found that cytotoxicity and antiproliferative effect of ginger extract and [6]-Gingerol could be associated with induction of apoptosis. The ginger ethanol extract and [6]-Gingerol also showed remarkable antioxidant activities in comparison with ascorbic acid and N-acetyl-L-cysteine.
Co-Authors Azian Murad, Noor Hanif, Harliansyah Wan Ngah, Wan Zurinah